ArticleThe Journal of biological chemistry2026
CEP55 promotes prostate cancer progression via TPX2-dependent activation of AURKA-PI3K-AKT signaling and inhibition of ferroptosis.
Article in The Journal of biological chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Prostate cancer (PCa) is a highly heterogeneous malignancy with variable clinical outcomes. Centrosomal protein 55 (CEP55) has been involved in the progression of multiple cancers, but its function in PCa is still largely uncharacterized. CEP55 expression was evaluated in clinical samples and cell lines via bioinformatics analysis, quantitative RT-PCR, and Western blot. Functional assessments, such as wound healing, Cell Counting Kit-8, and Transwell invasion, were carried out to evaluate the impact of CEP55 upregulation or knockdown on PCa cell growth and metastasis. Coimmunoprecipitation was utilized to observe the interaction between CEP55 and TPX2 microtubule nucleation factor. The role of CEP55 in ferroptosis regulation was assessed by measuring IC
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