Evidence map›Paper›PMID 41616833›Full record

ArticleMolecular and cellular endocrinology2026

2-Hydroxyestradiol regulates extracellular matrix deposition through estrogen receptor beta activation in airway smooth muscle cells.

Ashish Kumar, Mohammad Irshad Reza, Anurag Banerjee, Nilesh Sudhakar Ambhore, Premanand Balraj, Buddhadev Layek, Michael A Thompson, John R Hawse, Christina M Pabelick, Y S Prakash and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular and cellular endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ashish KumarSection of Pulmonary, Critical Care & Sleep Medicine, Department of Internal Medicine, The University of Oklahoma Health Campus, Oklahoma City, OK, USA; Department of Pharmaceutical Sciences, North Dakota State University, Fargo, ND, USA.
Mohammad Irshad RezaSection of Pulmonary, Critical Care & Sleep Medicine, Department of Internal Medicine, The University of Oklahoma Health Campus, Oklahoma City, OK, USA; Department of Pharmaceutical Sciences, North Dakota State University, Fargo, ND, USA.
Anurag BanerjeeDepartment of Pharmaceutical Sciences, North Dakota State University, Fargo, ND, USA.
Nilesh Sudhakar AmbhoreDepartment of Pharmaceutical Sciences, North Dakota State University, Fargo, ND, USA.
Premanand BalrajDepartment of Pharmaceutical Sciences, North Dakota State University, Fargo, ND, USA.
Buddhadev LayekDepartment of Pharmaceutical Sciences, North Dakota State University, Fargo, ND, USA.
Michael A ThompsonDepartment of Anesthesiology and Perioperative Medicine, USA; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
John R HawseDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.
Christina M PabelickDepartment of Anesthesiology and Perioperative Medicine, USA; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
Y S PrakashDepartment of Anesthesiology and Perioperative Medicine, USA; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
Venkatachalem SathishSection of Pulmonary, Critical Care & Sleep Medicine, Department of Internal Medicine, The University of Oklahoma Health Campus, Oklahoma City, OK, USA; Department of Pharmaceutical Sciences, North Dakota State University, Fargo, ND, USA. Electronic address: sathish-venkatachalem@ou.edu.

Funding

Kisspeptins in the AirwayR01HL146705 · NHLBI · NORTH DAKOTA STATE UNIVERSITY · PI VENKATACHALEM, SATHISH · 2020 to 2024
$2.2M
Nicotine, Airway Smooth Muscle and AsthmaR01HL142061 · NHLBI · MAYO CLINIC ROCHESTER · PI PABELICK, CHRISTINA MARIA, PRAKASH, Y. S. · 2019 to 2022
$2.0M
Estrogen signaling in chronic asthmaR01HL173391 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI VENKATACHALEM, SATHISH · 2025 to 2025
$1.0M
NHLBI NIH HHS R01 HL142061NHLBI NIH HHS R01 HL146705NHLBI NIH HHS R01 HL173391
6 · The paper itself

Abstract

Airway remodeling in asthma is characterized by increased extracellular matrix (ECM) production and deposition by airway smooth muscle (ASM) cells. Existing studies have shown contrasting effects of 17β-estradiol (E

Indexed as

EstriolEstrogen Receptor betaExtracellular MatrixLungMyocytes, Smooth MuscleAirway RemodelingCells, CulturedEstrogen Receptor alphaEstrogens, CatecholHumansMolecular Docking SimulationProtein BindingProtein Structure, TertiaryRNA, MessengerRNA, Small InterferingSignal Transduction2-hydroxyestriolEstriolEstrogen Receptor alphaEstrogen Receptor betaEstrogens, CatecholRNA, MessengerRNA, Small InterferingAirway remodelingAirway smooth muscleAsthmaEstrogen metabolitesEstrogen receptorsExtracellular matrix

Identifiers

PMID41616833
PMCPMC12888803

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.