Evidence map›Paper›PMID 41616828›Full record

ArticleJournal of lipid research2026

Spatial mapping of CoQ10 repletion by BPM31510 in a genetic mouse model (Coq4

Eliana Barriocanal-Casado, Sylwia A Stopka, Alba Pesini, Juan J Aristizabal-Henao, Srada Karmacharya, Devon Van Cura, Ryan Zhang, Kelsey R Nickerson, Kashni Grover, Oksana Zavidij and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of lipid research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. BPM31510 Increases the CoQ Pool in Chemically Induced CoQ-Deficient Cells, CoQ-Deficient Patient Fibroblasts, and in Metabolically Active Murine Tissues.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Eliana Barriocanal-CasadoDepartment of Neurology, Columbia University Irving Medical Center, New York, NY, USA.
Sylwia A StopkaBPGbio, Waltham, MA, USA.
Alba PesiniDepartment of Neurology, Columbia University Irving Medical Center, New York, NY, USA.
Juan J Aristizabal-HenaoBPGbio, Waltham, MA, USA.
Srada KarmacharyaBPGbio, Waltham, MA, USA.
Devon Van CuraBPGbio, Waltham, MA, USA.
Ryan ZhangBPGbio, Waltham, MA, USA.
Kelsey R NickersonBPGbio, Waltham, MA, USA.
Kashni GroverBPGbio, Waltham, MA, USA.
Oksana ZavidijBPGbio, Waltham, MA, USA.
Sarah R WesselBPGbio, Waltham, MA, USA.
Niven R NarainBPGbio, Waltham, MA, USA; Department of Molecular Biology, Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.
Vijay ModurBPGbio, Waltham, MA, USA.
Stephane GestaBPGbio, Waltham, MA, USA.
Michael A KiebishBPGbio, Waltham, MA, USA. Electronic address: michael.kiebish@bpgbio.com.
Catarina M QuinziiDepartment of Neurology, Columbia University Irving Medical Center, New York, NY, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Primary coenzyme Q10 (CoQ10) deficiency is a rare mitochondrial disorder caused by mutations in genes involved in CoQ biosynthesis (e.g., COQ4) that result in impaired mitochondrial respiration, oxidative stress, and dysfunction across multiple organ systems because of decreased mitochondrial levels of CoQ10. Although oral CoQ10 supplementation has been examined for standard of care, poor absorption and inadequate tissue and intracellular distribution have resulted in a lack of clinically significant efficacy. BPM31510 is a lipid nanoparticle containing oxidized CoQ10 designed to improve bioavailability and targeted uptake into the mitochondria. In the current study, we assessed the efficacy of BPM31510 to increase CoQ levels in Coq4

Indexed as

AtaxiaMitochondrial DiseasesMuscle WeaknessUbiquinoneAnimalsDisease Models, AnimalMaleMiceNanoparticlescoenzyme Q10UbiquinoneCoQ10 deficiencyMALDImitochondrial diseaseMSMSIquinomics

Identifiers

PMID41616828
PMCPMC13080569

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.