Evidence map›Paper›PMID 41616823›Full record

ArticleCellular and molecular gastroenterology and hepatology2026

Dietary Stearic Acid Accelerates Intestinal Tumorigenesis via Fatty Acid-binding Protein 5 Without Promoting Obesity.

Kazuaki Nakata, Seiga Komiyama, Keisuke Sekine, Motoyoshi Nagai, Takuma Okawa, Wakana Ohashi, Kenta Nakano, Tadashi Okamura, Takuma Kozono, Nobuyuki Takemura and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular gastroenterology and hepatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Kazuaki NakataClinical Research Advancement Section, National Institute of Global Health and Medicine, Japan Institute for Health Security, Tokyo, Japan.
Seiga KomiyamaDivision of Biochemistry, Faculty of Pharmacy and Graduate School of Pharmaceutical Science, Keio University, Tokyo, Japan.
Keisuke SekineLaboratory of Cancer Cell Systems, National Cancer Center Research Institute, Tokyo, Japan.
Motoyoshi NagaiClinical Research Advancement Section, National Institute of Global Health and Medicine, Japan Institute for Health Security, Tokyo, Japan; Division of Biochemistry, Faculty of Pharmacy and Graduate School of Pharmaceutical Science, Keio University, Tokyo, Japan.
Takuma OkawaDivision of Biochemistry, Faculty of Pharmacy and Graduate School of Pharmaceutical Science, Keio University, Tokyo, Japan.
Wakana OhashiDivision of Biochemistry, Faculty of Pharmacy and Graduate School of Pharmaceutical Science, Keio University, Tokyo, Japan.
Kenta NakanoDepartment of Laboratory Animal Medicine, National Institute of Global Health and Medicine, Japan Institute for Health Security, Tokyo, Japan.
Tadashi OkamuraDepartment of Laboratory Animal Medicine, National Institute of Global Health and Medicine, Japan Institute for Health Security, Tokyo, Japan.
Takuma KozonoDepartment of Applied Biological Science, Tokyo University of Agriculture and Technology, Tokyo, Japan.
Nobuyuki TakemuraDepartment of Surgery, National Center for Global Health and Medicine, Japan Institute for Health Security, Tokyo, Japan.
Kazuhiko YamadaDepartment of Surgery, National Center for Global Health and Medicine, Japan Institute for Health Security, Tokyo, Japan; Course of Advanced and Specialized Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Norihiro KokudoDepartment of Surgery, National Center for Global Health and Medicine, Japan Institute for Health Security, Tokyo, Japan.
Taeko DohiClinical Research Advancement Section, National Institute of Global Health and Medicine, Japan Institute for Health Security, Tokyo, Japan; Division of Biochemistry, Faculty of Pharmacy and Graduate School of Pharmaceutical Science, Keio University, Tokyo, Japan.
Koji HaseDivision of Biochemistry, Faculty of Pharmacy and Graduate School of Pharmaceutical Science, Keio University, Tokyo, Japan; Institute of Fermentation Sciences (IFeS), Faculty of Food and Agricultural Sciences, Fukushima University, Fukushima, Japan; International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo (IMSUT), Tokyo, Japan.
Yuki I KawamuraClinical Research Advancement Section, National Institute of Global Health and Medicine, Japan Institute for Health Security, Tokyo, Japan; Course of Advanced and Specialized Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan. Electronic address: kawamura.y@jihs.go.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND &

aimsDietary fat increases the risk of intestinal cancer, but the effect of the fatty acid composition on tumorigenesis is unclear. The aim of this study is to investigate the impact of diets with different fatty acids on carcinogenesis in the intestine.

methodsMice were fed a linoleic acid (LA)-rich or stearic acid (SA)-rich high-fat diet (HFD) from the age of 4 weeks. The Apc

resultsWe found that an SA-rich HFD more strongly accelerated tumorigenesis in murine CRC models than an LA-rich HFD, with fewer obesity phenotypes compared with LA-rich HFD-fed mice. Dietary SA more strongly promoted epithelial cell proliferation and Paneth cell differentiation than LA, whereas no differences in the numbers of leucine-rich repeat-containing G protein-coupled receptor 5

conclusionsDietary SA can promote CRC via FABP5 without promoting obesity.

Indexed as

CarcinogenesisColorectal NeoplasmsDietary FatsFatty Acid-Binding ProteinsObesityStearic AcidsAnimalsCell DifferentiationCell ProliferationDiet, High-FatDisease Models, AnimalHumansIntestinal MucosaLinoleic AcidMaleMiceDietary FatsFabp5 protein, mouseFatty Acid-Binding ProteinsLinoleic AcidNeoplasm Proteinsstearic acidStearic AcidsColorectal CancerDietary Fatty AcidIntestinal Epithelial Cell

Identifiers

PMID41616823
PMCPMC12990346

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.