Evidence map›Paper›PMID 41616287›Full record

ArticleJournal of the American Chemical Society2026

Expedient Synthesis of

Philip Kohnke, Liming Zhang

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Philip KohnkeDepartment of Chemistry & Biochemistry, University of California, Santa Barbara, California 93106, United States.
Liming ZhangDepartment of Chemistry & Biochemistry, University of California, Santa Barbara, California 93106, United States.ORCID 0000-0002-5306-1515

Funding

Research Supplements to Promote Diversity in Health-Related ResearchR35GM139640 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI Liming Zhang · 2021 to 2026
$2.5M
NIGMS NIH HHS R35 GM139640
6 · The paper itself

Abstract

Unnatural amino acids play a pivotal role in protein engineering and drug discovery. However, their efficient and enantioselective synthesis remains a central challenge in organic chemistry. Here, we describe a concise and practical two-step approach for the synthesis of diverse unnatural amino acid building blocks from readily available terminal alkynes. This method utilizes mild gold(I) catalysis in combination with inexpensive chiral

Indexed as

Amino AcidsPeptidesAlkynesCatalysisStereoisomerismAlkynesAmino AcidsPeptides

Identifiers

PMID41616287
PMCPMC13023387

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.