Evidence map›Paper›PMID 41616268›Full record

ArticlemBio2026

A combination of proviral and antiviral roles of CD11c- and T-bet-expressing B cells defines parameters of chronic murine gammaherpesvirus infection.

Erika R Johansen, Xander G Bradeen, Emily V Xie, Bonnie N Dittel, Elizabeth A Leadbetter, Vera L Tarakanova

Abstract read
In one paragraph

Article in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Erika R JohansenDepartment of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.ORCID 0009-0009-5220-5028
Xander G BradeenDepartment of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Emily V XieMedical Scientist Training Program, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Bonnie N DittelDepartment of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Elizabeth A LeadbetterDepartment of Microbiology, Immunology & Molecular Genetics, UT Health San Antonio Long School of Medicine, San Antonio, Texas, USA.
Vera L TarakanovaDepartment of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.ORCID 0000-0002-9499-088X

Funding

Gammaherpesvirus protein kinase: a master manipulator of the host during chronic infection.R01AI165578 · NIAID · MEDICAL COLLEGE OF WISCONSIN · PI Vera L. Tarakanova · 2022 to 2026
$2.3M
From friend to foe: proviral role of IRF-3 in chronic gammaherpesvirus infectionR21AI182596 · NIAID · MEDICAL COLLEGE OF WISCONSIN · PI TARAKANOVA, VERA L. · 2024 to 2025
$440k
Uncovering the proviral role of B cell-intrinsic STAT1 expression during chronic gammaherpesvirus infectionF31AI191670 · NIAID · MEDICAL COLLEGE OF WISCONSIN · PI Erika R Johansen · 2025 to 2026
$100k
NIAID NIH HHS F31 AI191670NIAID NIH HHS R01 AI165578NIAID NIH HHS R21 AI182596
6 · The paper itself

Abstract

Gammaherpesviruses are ubiquitous pathogens that establish lifelong infection and are associated with the development of cancer and multiple sclerosis. Unlike other viral families, gammaherpesviruses selectively target B cells to establish chronic infection. Specifically, gammaherpesvirus-driven differentiation of latently infected cells through the germinal center supports chronic infection and seeds viral lymphomagenesis. CD11c

Indexed as

B-LymphocytesCD11c AntigenGammaherpesvirinaeHerpesviridae InfectionsT-Box Domain ProteinsAnimalsCD11 AntigensCell DifferentiationGerminal CenterMiceMice, Inbred C57BLPersistent InfectionT-bet Transcription FactorVirus LatencyCD11 AntigensCD11c AntigenItgax protein, mouseT-bet Transcription FactorT-Box Domain Proteinsage-associated B cellschronic infectiongammaherpesvirusgerminal center responselatent reservoirself-reactive B cellsT-bet-expressing B cells

Identifiers

PMID41616268
PMCPMC12977465

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.