Evidence map›Paper›PMID 41616100›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Redefining the Health Risk of Battery Materials Through a Biologically Transformed Metal Mixture.

Ze Zhang, Gan Miao, Xueyu Zhang, Zhao Shu, Dawei Lu, Yujie Song, Shanfa Yu, Qian Liu, Yang Song, Rong Zhang and 2 more

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ze ZhangDepartment of Occupational Health and Environmental Health, School of Public Health, Qingdao University, Qingdao, China.
Gan MiaoDepartment of Occupational Health and Environmental Health, School of Public Health, Qingdao University, Qingdao, China.
Xueyu ZhangDepartment of Occupational Health and Environmental Health, School of Public Health, Qingdao University, Qingdao, China.
Zhao ShuState Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
Dawei LuState Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
Yujie SongDepartment of Occupational Health and Environmental Health, School of Public Health, Qingdao University, Qingdao, China.
Shanfa YuDepartment of Public Health, Henan Medical College, Zhengzhou, China.
Qian LiuState Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
Yang SongState Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
Rong ZhangDepartment of Toxicology, School of Public Health, Hebei Medical University, Shijiazhuang, China.
Xiaoting JinDepartment of Occupational Health and Environmental Health, School of Public Health, Qingdao University, Qingdao, China.ORCID https://orcid.org/0000-0002-6526-8046
Yuxin ZhengDepartment of Occupational Health and Environmental Health, School of Public Health, Qingdao University, Qingdao, China.

Funding

National Natural Science Foundation of China 22222610National Natural Science Foundation of China 82241086National Natural Science Foundation of China 82473609National Natural Science Foundation of China 82473674National Natural Science Foundation of China U24A20772Qingdao Natural Science Foundation 24-4-4-zrjj-157-jch
6 · The paper itself

Abstract

The global transition to electric vehicles hinges on lithium-ion batteries, yet the health risks of their core components, such as nickel-manganese-cobalt (NCM) cathodes, remain a critical and misunderstood gap, threatening a truly sustainable energy transition. Herein, we reveal that inhaled NCM particles undergo sustained lysosomal dissolution, transforming into metal mixtures whose composition mirrors the parent material. Crucially, we decipher the unique toxicological interactions within this biologically generated mixture-antagonism from Ni/Co and synergy from Mn. This fundamental discovery of NCM's biological fate unlocks accurate risk assessment. Building on this mechanistic insight, we identified the Integrated Addition and Interaction (IAI) model as the framework capable of capturing complex interactions. Applying this model to real-world exposure data uncovers moderate yet significant population-level health risks. Our work establishes a transformative, evidence-based paradigm that connects in-body material transformation to real-world health outcomes, providing the scientific foundation to ensure that the clean energy transition is not only green but fundamentally safe for human well-being.

Indexed as

CobaltElectric Power SuppliesLithiumManganeseMetalsNickelHumansRisk AssessmentCobaltLithiumManganeseMetalsNickelbiological transformationhealth risk paradigmlithium‐ion batterymetal mixture toxicologysustainable energy materials

Identifiers

PMID41616100
PMCPMC13045502

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.