Evidence map›Paper›PMID 41615870›Full record

ArticleMedical principles and practice : international journal of the Kuwait University, Health Science Centre2026

Role of Specific miRNA Expression and Nuclear Kappa B Gene Polymorphism as Potential Diagnostic Markers for Chronic Myeloid Leukemia.

Jehad F Alhmoud, Moath Alqaraleh, Sarah N Dala-Ali, Leen S Alhiary, Issa I Dababneh, Nada L Odeh, Nirmeen Elzogheir, Dana A Alqudah, Futoon Abedrabbu Al-Rawashde

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Article in Medical principles and practice : international journal of the Kuwait University, Health Science Centre, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Jehad F AlhmoudDepartment of Medical Laboratory Sciences, Jordan University of Science and Technology, Irbid, Jordan, jfalhmoud@just.edu.jo.
Moath AlqaralehDepartment of Medical Laboratory Sciences, Faculty of Allied Medical Sciences, Al-Balqa Applied University, Salt, Jordan.
Sarah N Dala-AliDepartment of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, Al-Ahliyya Amman University, Amman, Jordan.
Leen S AlhiaryDepartment of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, Al-Ahliyya Amman University, Amman, Jordan.
Issa I DababnehDepartment of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, Al-Ahliyya Amman University, Amman, Jordan.
Nada L OdehDepartment of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, Al-Ahliyya Amman University, Amman, Jordan.
Nirmeen ElzogheirCell Therapy Center, The University of Jordan, Amman, Jordan.
Dana A AlqudahCell Therapy Center, The University of Jordan, Amman, Jordan.
Futoon Abedrabbu Al-RawashdeDepartment of Medical Laboratory Sciences, Faculty of Allied Medical Sciences, Al-Balqa Applied University, Salt, Jordan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

<p>Objective: This study assesses microRNA-21 (miR-21) and microRNA-302 (miR-302) levels and examines their association with a nuclear factor kappa-light-chain enhancer of activated B cells (NF-κB) gene single nucleotide polymorphism (SNP) in chronic myeloid leukemia (CML) patients, aiming to identify these miRNAs as potential diagnostic biomarkers. The findings could contribute to improved diagnostic and treatment approaches. SUBJECT AND

methodsThis study involved 65 patients with CML at Al-Basheer Hospital, Amman, Jordan, and 30 healthy controls. Hematological parameters were analyzed via complete blood count. Gene expression was assessed by real-time PCR to analyze miRNA and NF-KB SNPs in patients' plasma.

resultsA highly significant difference (p < 0.0001) was observed, indicating that miR-21 expression was higher in CML patients compared to the controls. miR-302 levels were lower in CML patients. The NF-κB Del/Del genotype was associated with a higher white blood cell count compared to the Ins/Ins and Ins/Del genotypes. Platelet counts varied among the CML patients with three polymorphisms.

conclusionmiR-21 is elevated in CML patients, suggesting an oncogenic role. Our results suggest that miR-302 may serve as a prognostic and diagnostic biomarker. The NF-κB1 gene rs28362491 Del/Del genotype may be associated with an increased risk of CML. Identification of these biomarkers can contribute significantly to improve both diagnosis and treatment strategies. </p>.

Indexed as

Leukemia, Myelogenous, Chronic, BCR-ABL PositiveMicroRNAsNF-kappa BAdultAgedBiomarkers, TumorCase-Control StudiesFemaleGenotypeHumansJordanMaleMiddle AgedPolymorphism, Single NucleotideBiomarkers, TumorMicroRNAsMIRN21 microRNA, humanMIRN302A microRNA, humanNF-kappa BChronic myeloid leukemiaHematological parametersmiR-21miR-302Myeloproliferative neoplasmNF-κB rs28362491

Identifiers

PMID41615870
PMCPMC13065331

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