SynthesisClinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
Effectiveness and Safety of Oxidized Regenerated Cellulose for Hemostasis in Joint Arthroplasty: A Systematic Review and Meta-Analysis.
Synthesis in Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Preoperative Hemoglobin Discriminates Perioperative Transfusion in Reverse Shoulder Arthroplasty: A Single-Center Preliminary Study with Internal Validation and a Candidate Blood-Preparation Threshold.Medicina (Kaunas, Lithuania) · 2026Article
- Topical oxidized regenerated cellulose for perioperative blood management in total hip and knee arthroplasty: a systematic review and meta-analysis.Frontiers in surgery · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BackgroundOxidized regenerated cellulose (ORC) is a topical hemostatic agent, but its efficacy and safety in arthroplasty remain inconclusive. This meta-analysis aimed to comprehensively assess its role in this procedure.MethodsWe systematically searched multiple databases up to July 30, 2025, for cohort studies and randomized controlled trials investigating the use of ORC in arthroplasty. Study quality was assessed using standard tools, and data were analyzed using Stata software.ResultsA total of 33 articles were retrieved. After removing 27 duplicates, six high-quality studies involving 684 participants were included in the analysis. The analysis revealed that ORC significantly reduced total blood loss (WMD = -102.50 mL, 95% CI: -201.75, -3.26, I
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.