Evidence map›Paper›PMID 41615782›Full record

ArticleJournal of Parkinson's disease2026

VR-based quantitative oculomotor analysis and association with regional brain atrophy in MSA.

You Fu, Linlin Wan, Zhao Chen, Chunrong Wang, Daji Chen, Riwei Ouyang, Xiaokang Wu, Xiafei Long, Kefang Du, Xinying Xiao and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Parkinson's disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

15 authors.

You FuDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Linlin WanDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Zhao ChenDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Chunrong WangKey Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, Hunan, 410008, China.
Daji ChenDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Riwei OuyangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Xiaokang WuDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Xiafei LongDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Kefang DuDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Xinying XiaoDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Ruqing HeDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Linliu PengDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Rong QiuSchool of Computer Science and Engineering, Central South University, Changsha, Hunan, 410083, China.
Beisha TangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Hong JiangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.ORCID 0000-0003-2812-4120

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BackgroundThe quantitative assessment of the oculomotor system has emerged as a promising biomarker for neurodegenerative disorders. Although oculomotor impairments are commonly observed in multiple system atrophy (MSA) patients, the specific abnormalities and underlying neural structural changes remain poorly understood.ObjectivesTo explore oculomotor abnormalities and associated brain changes in MSA, evaluating their potential as biomarkers for diagnosis and disease monitoring.MethodsA total of 100 MSA patients and 50 healthy controls (HCs) were included in this study. All subjects underwent comprehensive evaluations, including clinical assessments, virtual reality (VR)-based ocular-tracking tasks and structural magnetic resonance imaging (MRI).ResultsCompared with HCs, MSA patients showed significantly impaired smooth pursuit (SP) with increased number of deviations (13.33 [29.33] vs. 5.67 [7.67],

Indexed as

BrainMultiple System AtrophyOcular Motility DisordersPursuit, SmoothVirtual RealityAgedAtrophyEye-Tracking TechnologyFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedSaccadesbiomarkereye movementsmultiple system atrophyoculomotor deficitsstructural MRI

Identifiers

PMID41615782
PMCPMC13347584

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.