Evidence map›Paper›PMID 41615761›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

PLETHORA-autophagy axis activates organ regeneration through ROS modulation.

Akansha Ganguly, Aabha Humnabadkar, Komal Gautam, Viola Willemsen, Lin Xu, Yasin Dagdas, Kalika Prasad

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. More than a blueprint: Developmental regulators secure the cellular environment for regeneration.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. PLETHORA-autophagy axis activates organ regeneration through ROS modulation.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Akansha GangulyDepartment of Biology, Indian Institute of Science Education and Research, Pune 411008, India.ORCID 0009-0001-5560-5491
Aabha HumnabadkarDepartment of Biology, Indian Institute of Science Education and Research, Pune 411008, India.ORCID 0009-0008-4110-9068
Komal GautamDepartment of Biology, Indian Institute of Science Education and Research, Pune 411008, India.ORCID 0009-0008-6851-6165
Viola WillemsenCluster of Plant Developmental Biology, Cell and Developmental Biology, Wageningen University & Research, Droevendaalsesteeg 1, Wageningen 6708 PB, The Netherlands.ORCID 0000-0002-6420-0605
Lin XuKey Laboratory of Plant Carbon Capture, Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200032, China.ORCID 0000-0003-4718-1286
Yasin DagdasCentre for Organismal Studies, Heidelberg University, Heidelberg 69120, Germany.ORCID 0000-0002-9502-355X
Kalika PrasadDepartment of Biology, Indian Institute of Science Education and Research, Pune 411008, India.ORCID 0000-0001-8666-856X

Funding

Anusandhan National Research Foundation - Advanced Research Grant (ANRF-ARG), Government of India ANRF/ARG/2025/008174/LSDepartment of Biotechnology, Ministry of Science and Technology, India (DBT) BT/PR41931/BRB/10/1964/2021Department of Biotechnology, Ministry of Science and Technology, India (DBT) BT/PR54722/BSA/33/509/2025DST | Science and Engineering Research Board (SERB) SPR/2021/000109
6 · The paper itself

Abstract

Injury-induced disruption of cellular homeostasis leads to accumulation of stress at sites adjacent to a wound. How do these cells mitigate wound-induced stress and restore cellular homeostasis to promote regeneration? To address this question, we examined the role of autophagy-a conserved quality control pathway that recycles defective cellular components to sustain cellular homeostasis-in facilitating wound repair in plants. We demonstrate that transcriptional activation of autophagy-related gene 8 (

Indexed as

ArabidopsisArabidopsis ProteinsAutophagyReactive Oxygen SpeciesRegenerationTranscription FactorsGene Expression Regulation, PlantPlant RootsArabidopsis ProteinsPLT2 protein, ArabidopsisReactive Oxygen SpeciesTranscription Factorsautophagyde novo root regenerationPLETHORAROSstem cell

Identifiers

PMID41615761
PMCPMC12890791

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.