ArticleProceedings of the National Academy of Sciences of the United States of America2026
REV-ERB-alpha and -beta coordinately regulate astrocyte reactivity and proteostatic function.
Collin J Nadarajah, Michelle Y Li, Elsa I Quillin, Kevin Boyer, Julie M Dimitry, Yining Chen, Melvin W King, Ibrahim O Saliu, Jiyeon Lee, Patrick W Sheehan and 4 more
Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
14 authors.
Collin J NadarajahDepartment of Neurology, Washington University School of Medicine, St. Louis, MO 63110.
Michelle Y LiDepartment of Neurology, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0009-0006-0924-9947
Elsa I QuillinDepartment of Neurology, Washington University School of Medicine, St. Louis, MO 63110.
Kevin BoyerDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110.
Julie M DimitryDepartment of Neurology, Washington University School of Medicine, St. Louis, MO 63110.
Yining ChenDepartment of Neurology, Washington University School of Medicine, St. Louis, MO 63110.
Melvin W KingDepartment of Neurology, Washington University School of Medicine, St. Louis, MO 63110.
Ibrahim O SaliuDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0002-6182-5992
Jiyeon LeeDepartment of Neurology, Washington University School of Medicine, St. Louis, MO 63110.
Patrick W SheehanDepartment of Neurology, Washington University School of Medicine, St. Louis, MO 63110.
Albert A DavisDepartment of Neurology, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0003-2042-8445
Mitchell A LazarDepartment of Medicine, Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.ORCID 0000-0001-8653-1280
Guoyan ZhaoDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0001-5615-6774
Erik S MusiekDepartment of Neurology, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0002-8873-0360
Funding
REV-ERB Nuclear Receptors in Circadian Rhythm and MetabolismR01DK045586 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI MITCHELL A. LAZAR · 1992 to 2026
$12.0M
ROLE OF GLIAL CIRCADIAN CLOCK DYSFUNCTION IN THE PATHOGENESIS OF ALZHEIMER'S DISEASER01AG054517 · NIA · WASHINGTON UNIVERSITY · PI Erik Steven Musiek · 2017 to 2026
$4.5M
Neuroscience Training Program at Washington UniversityT32NS121881 · NINDS · WASHINGTON UNIVERSITY · PI Martha W Bagnall, Daniel Kerschensteiner · 2021 to 2026
$3.1M
Role of REV-ERB Proteins in Neuroinflammation and Alzheimer's DiseaseR01AG063743 · NIA · WASHINGTON UNIVERSITY · PI Erik Steven Musiek, Thomas Papouin · 2020 to 2026
$2.6M
Evaluating novel transcription factors in regulating astrocyte identity, reactivity, and their roles in neurodegenerative disease pathogenesisR21AG089851 · NIA · WASHINGTON UNIVERSITY · PI MUSIEK, ERIK STEVEN, ZHAO, GUOYAN · 2024 to 2024
$428k
HHS | NIH | National Institute on Aging (NIA) R01AG05451707HHS | NIH | National Institute on Aging (NIA) R01AG06374304HHS | NIH | National Institute on Aging (NIA) R21AG089851HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases (DEM) R01DK45586NIA NIH HHS R01 AG054517NIA NIH HHS R01 AG063743NIA NIH HHS R21 AG089851NIDDK NIH HHS R01 DK045586NINDS NIH HHS T32 NS121881
6 · The paper itself
Abstract
The molecular circadian clock is a ubiquitous transcriptional-translational feedback loop that regulates CNS function, glial responses, and neurodegenerative pathology. The nuclear receptors REV-ERB-α (
Indexed as
AstrocytesNuclear Receptor Subfamily 1, Group D, Member 1ProteostasisReceptors, Cytoplasmic and NuclearRepressor ProteinsAnimalsBrainCircadian ClocksMiceMice, KnockoutNr1d1 protein, mouseNr1d2 protein, mouseNuclear Receptor Subfamily 1, Group D, Member 1Receptors, Cytoplasmic and NuclearRepressor Proteinsalpha-synucleinastrocytecircadianneuroinflammationREV-ERBalpha
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
REV-ERB-alpha and -beta coordinately regulate astrocyte reactivity and proteostatic function. · full record | OpenQuestion