Evidence map›Paper›PMID 41615608›Full record

ArticleDoklady. Biochemistry and biophysics2025

Investigating the Role of Membrane Environment in the Recognition of GD2 Ganglioside with Antibodies.

M S Sokolova, V A Zubricheva, E M Rapoport, D O Anisimova, I I Mikhalyov, R V Kholodenko, N V Bovin, I M Ryzhov

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Article in Doklady. Biochemistry and biophysics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

M S SokolovaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
V A ZubrichevaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
E M RapoportShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
D O AnisimovaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
I I MikhalyovShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
R V KholodenkoShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
N V BovinShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
I M RyzhovShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia. imryzhov@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antibodies to the ganglioside GD2 are used therapeutically, although the mechanism of their interaction with tumor cells antigen is poorly understood. To study the effect of membrane environment on GD2 recognition by antibodies, three synthetic glycolipids-analogs of the ganglioside GD2-were obtained. These glycolipids differed in the length of their spacers and the type of lipid moiety. When inserted in the membrane of endothelial cells, they interacted with anti-GD2 antibodies in a paradoxical manner: the spatially most hindered variant (where the oligosaccharide is located in tight proximity to the membrane) interacted better than the others.

Indexed as

AntibodiesCell MembraneGangliosidesAnimalsEndothelial CellsHumansAntibodiesganglioside, GD2Gangliosides

Identifiers

PMID41615608

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.