Evidence map›Paper›PMID 41615607›Full record

ArticleDoklady. Biochemistry and biophysics2025

Interaction of Human Peripheral NK Cells with Bacterial Polysaccharides.

A A Boyko, L M Kanevskiy, E M Rapoport, A B Tuzikov, N V Shilova, E I Kovalenko

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Article in Doklady. Biochemistry and biophysics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

A A BoykoShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia. boyko_anna@mail.ru.
L M KanevskiyShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
E M RapoportShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
A B TuzikovShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
N V ShilovaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
E I KovalenkoShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

NK cells participate in the antimicrobial immune response. NK cell activation by bacterial polysaccharides (PSs) can occur indirectly through signals from other immune cells or through direct influence of PSs on NK cells via interaction with activating receptors. This study demonstrated that peripheral NK cells bind fluorescently labeled PSs from the Gram-negative bacteria Escherichia coli, Shigella flexneri, and Pseudomonas aeruginosa with varying efficiency depending on the PS origin and the NK cell donor. PSs from Escherichia coli strain O19ab induced an increased IFN-γ production by NK cells in the absence of high levels of PS binding to the cell surface. The obtained results provide new insights into the interactions of NK cells with polysaccharides and open new prospects for understanding the NK cell-mediated immune response to bacterial infections.

Indexed as

Killer Cells, NaturalPolysaccharides, BacterialEscherichia coliHumansInterferon-gammaPseudomonas aeruginosaInterferon-gammaPolysaccharides, Bacterialbacterial polysaccharidesIFN-γ productionNK cells

Identifiers

PMID41615607

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.