ArticleInternational journal of computer assisted radiology and surgery2026
Transient numerical simulation of hemodynamics in bioprosthetic heart valves: insights into valve sizing and thrombosis risk.
Article in International journal of computer assisted radiology and surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
purposeThis study aims to evaluate the hemodynamic effect of tilting after implantation of a bioprosthetic heart valve in an enlarged aortic annulus using computational fluid dynamics (CFD). The objective is to define the cost of excessive enlargement in transprosthetical flow and identify the optimal prosthesis size and implantation angle to reduce thrombosis and early degeneration.
methodsVirtual implantation of a 23-mm bioprosthetic model was conducted in a prespecified virtual aortic annulus of 23 mm. CFD simulations were conducted to analyze the hemodynamic parameters, including wall shear stress and turbulent kinetic energy, for bioprosthetic heart valves of the 23 mm (perpendicular implantation), 25 mm, and 27 mm (tilted implantation at different angles) after virtual annular enlargement. The simulations utilized transient flow models and mesh convergence studies, to ensure numerical accuracy and clinical relevance.
resultsThe 23-mm valve implanted without annular enlargement and in an aligned fashion to the annulus exhibited higher wall shear stress (WSS) and shear stress (SS) values than the 25-mm valve implanted at 12° tilted position and better hemodynamics than the 27-mm valve at 25° tilted position. The 25-mm valve after annular enlargement and implantation at 12° tilted position achieved the best hemodynamic performance together with a 23% and 7% reduction of WSS and SS as compared to the 23-mm valve.
conclusionsSlight oversizing and tilting after annular enlargement yields the best performance of an aortic bioprosthetic valve with lowest WSS and balanced turbulence.
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