Evidence map›Paper›PMID 41615548›Full record

ArticleHead and neck pathology2026

Circulating Tumor HPV DNA Kinetics for Squamous Cell Carcinoma of the Lacrimal Sac Treated with Chemoradiotherapy.

Jonathan J Paly, William C Faquin, Ross D Merkin, Shriya Shukla, Gjystina Lumaj, Samuli Eldfors, Qin Wang, Dipon Das, Daniel L Faden

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Head and neck pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jonathan J PalyMassachusetts General Hospital, Boston, MA, USA. jpaly@mgh.harvard.edu.
William C FaquinMassachusetts General Hospital, Boston, MA, USA.
Ross D MerkinMassachusetts General Hospital, Boston, MA, USA.
Shriya ShuklaMassachusetts Eye and Ear, Boston, MA, USA.
Gjystina LumajMassachusetts Eye and Ear, Boston, MA, USA.
Samuli EldforsMassachusetts Eye and Ear, Boston, MA, USA.
Qin WangMassachusetts Eye and Ear, Boston, MA, USA.
Dipon DasMassachusetts Eye and Ear, Boston, MA, USA.
Daniel L FadenMassachusetts General Hospital, Boston, MA, USA.

Funding

NIH R03 5R03DE030550
6 · The paper itself

Abstract

introductionLacrimal sac squamous cell carcinoma (LSSCC) is the most common tumor of the rare disease subsite of the nasolacrimal system. Circulating tumor DNA (ctDNA) has emerged as a biomarker for non-invasive monitoring of tumor burden and treatment response across a variety of solid tumors.

methodsIn this case study, we report on two patients with histologically confirmed HPV + (HPV16 and HPV33) LSSCC managed with definitive chemoradiotherapy who underwent serial ctDNA monitoring prior to, during, and following treatment using an ultrasensitive multi-feature HPV whole genome sequencing liquid biopsy.

resultsIn this case study, we report on two patients with histologically confirmed HPV + (HPV16 and HPV33) LSSCC managed with definitive chemoradiotherapy who underwent serial ctDNA monitoring prior to, during, and following treatment using an ultrasensitive multi-feature HPV whole genome sequencing liquid biopsy.

conclusionsThis report suggests that ctDNA monitoring is a feasible approach for detection and monitoring of HPV + LSSCC. We advocate for continued p16 immunohistochemistry in all squamous cell carcinomas arising in the lacrimal sac. Confirmation with HPV ISH or PCR should be performed given the potential impact on management and surveillance.

Indexed as

Carcinoma, Squamous CellCirculating Tumor DNAEye NeoplasmsLacrimal Apparatus DiseasesPapillomavirus InfectionsSquamous Cell Carcinoma of Head and NeckAgedChemoradiotherapyDNA, ViralFemaleHuman Papillomavirus VirusesHumansMaleMiddle AgedCirculating Tumor DNADNA, Viral

Identifiers

PMID41615548
PMCPMC12858679

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.