Evidence map›Paper›PMID 41615547›Full record

ReviewHead and neck pathology2026

Novel Case of a Molecularly Confirmed Low-Grade Fibromyxoid Sarcoma of the Floor of the Mouth and Literature Review.

Eugene G Bestman, John K Brooks, Scott D Nelson, Ahmed S Sultan, Njood Hawari, Samantha L Jeffrey, Jettie Uyanne, Felix Kyle Yip, Kevin Artis, Manando Nakasaki

Erratum issuedAbstract readCase ReportsReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Head and neck pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Eugene G BestmanDepartment of Oral and Maxillofacial Surgery, Harbor-UCLA Medical Center, 1000 W Carson Street, Torrance, Los Angeles, CA, 90502, USA. ebestman@dhs.lacounty.gov.
John K BrooksDepartment of Oncology and Diagnostic Sciences, University of Maryland School of Dentistry, Baltimore, MD, USA.ORCID http://orcid.org/0000-0001-6634-8470
Scott D NelsonDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Ahmed S SultanDepartment of Oncology and Diagnostic Sciences, University of Maryland School of Dentistry, Baltimore, MD, USA.ORCID http://orcid.org/0000-0001-5286-4562
Njood HawariDepartment of Oncology and Diagnostic Sciences, Oral and Maxillofacial Pathology, University of Maryland School of Dentistry, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-9376-5613
Samantha L JeffreySarcoma Oncology Research Center, Cancer Center of Southern California, Santa Monica, CA, USA.
Jettie UyanneDepartment of Oral and Maxillofacial Surgery, Harbor-UCLA Medical Center, 1000 W Carson Street, Torrance, Los Angeles, CA, 90502, USA.
Felix Kyle YipDepartment of Oral and Maxillofacial Surgery, Harbor-UCLA Medical Center, 1000 W Carson Street, Torrance, Los Angeles, CA, 90502, USA.
Kevin ArtisDepartment of Oral and Maxillofacial Surgery, Harbor-UCLA Medical Center, 1000 W Carson Street, Torrance, Los Angeles, CA, 90502, USA.
Manando NakasakiDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLow-grade fibromyxoid sarcoma (LGFMS) is a deceptively bland spindle cell neoplasm with malignant potential, most commonly arising in the extremities and trunk, and limited to at least110 cases in the head and neck. This report describes the first molecularly confirmed LGFMS of the floor of the mouth demonstrating a FUS::CREB3L2 gene fusion. CASE PRESENTATION: An 18-year-old male presented with a painless floor of mouth mass of 1-year duration that was clinically suspected to represent a ranula. The mass was subjected to excisional biopsy. Histological examination was salient for an infiltrating proliferation of bland spindle cells arranged in whorled patterns within a collagenous stroma with focal myxoid change.

resultsImmunohistochemical analysis revealed diffuse MUC4 expression, narrowing the diagnosis. Targeted RNA sequencing identified a FUS::CREB3L2 fusion involving FUS exon 6 and CREB3L2 exon 5, confirming LGFMS. At 1-year follow-up, the patient showed no clinical evidence of disease and no detectable circulating tumor DNA.

conclusionThis case highlights the critical role of molecular testing in the diagnosis of LGFMS and emphasizes the importance of appropriate management strategies, including aggressive local control and long-term surveillance, given the tumor's risk of late recurrence and distant metastasis.

Indexed as

FibrosarcomaMouth NeoplasmsAdolescentBasic-Leucine Zipper Transcription FactorsBiomarkers, TumorHumansMaleOncogene Proteins, FusionRNA-Binding Protein FUSBasic-Leucine Zipper Transcription FactorsBiomarkers, TumorCREB3L2 protein, humanFUS protein, humanOncogene Proteins, FusionRNA-Binding Protein FUSFloor of the mouthFUS::CREB3L2 fusionLow-grade fibromyxoid sarcomaMUC4

Identifiers

PMID41615547
PMCPMC12858700

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.