Evidence map›Paper›PMID 41615500›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2026

Sexual dysfunction in multiple sclerosis: the role of orexin-A and calpain-2 - a pilot study.

Firdevs Uluc, Bihter Gokce Celik, Seyda Karabork, Nevin Horasan, Sule Aydin Turkoglu, Mehmet Hamid Boztas

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Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Firdevs UlucInstitute of Health Sciences, Department of Interdisciplinary Neuroscience, Bolu Abant İzzet Baysal University, Bolu, Türkiye. firdevs.uluc@ibu.edu.tr.ORCID http://orcid.org/0000-0002-7983-4483
Bihter Gokce CelikInstitute of Health Sciences, Department of Interdisciplinary Neuroscience, Bolu Abant İzzet Baysal University, Bolu, Türkiye.ORCID http://orcid.org/0000-0002-6793-6888
Seyda KaraborkFaculty of Medicine, Department of Medical Microbiology, Bolu Abant İzzet Baysal University, Bolu, Türkiye.ORCID http://orcid.org/0000-0002-9026-4485
Nevin HorasanInstitute of Health Sciences, Department of Interdisciplinary Neuroscience, Bolu Abant İzzet Baysal University, Bolu, Türkiye.ORCID http://orcid.org/0000-0003-0562-5088
Sule Aydin TurkogluFaculty of Medicine, Department of Neurology, Bolu Abant İzzet Baysal University, Bolu, Türkiye.ORCID http://orcid.org/0000-0001-8616-832X
Mehmet Hamid BoztasFaculty of Medicine, Department of Mental Health and Diseases, Bolu Abant İzzet Baysal University, Bolu, Türkiye.ORCID http://orcid.org/0000-0001-6541-0666

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSexual dysfunction (SD) is a common autonomic symptom in patients with multiple sclerosis (pwMS), significantly affecting their quality of life. Alterations in serum levels of calpain-2 (CAPN2) and orexin-A (ORX-A) may contribute to SD development.

objectiveThis study aimed to assess the prevalence of SD in pwMS and investigate its association with serum CAPN2 and ORX-A levels.

methodsFifty-seven pwMS diagnosed with relapsing-remitting MS were enrolled. Participants completed the Arizona Sexual Experiences Scale (ASEX), Multiple Sclerosis Quality of Life-54 (MSQoL-54), Beck Depression Inventory (BDI), and Composite Autonomic Symptom Score-31 (COMPASS-31). Serum CAPN2 and ORX-A levels were measured by enzyme-linked immunosorbent assay (ELISA).

resultsSD prevalence was 50.9%. Age, gender, depression status, and serum ORX-A levels were significant predictors of SD. Serum ORX-A levels were significantly lower in pwMS with SD, while CAPN2 levels did not differ. Depression scores correlated moderately with autonomic dysfunction scores. Spinal cord lesions were not significantly associated with SD.

conclusionMultiple factors contribute to sexual dysfunction in pwMS. While serum calpain-2 levels did not show a significant association with SD in this study, reduced serum orexin-A levels appear to play a key role in its pathogenesis. Further research is needed to clarify the role of calpain-2 and other molecular mechanisms. Identification of biological markers such as orexin-A may improve management strategies for SD in MS.

Indexed as

CalpainMultiple Sclerosis, Relapsing-RemittingOrexinsSexual Dysfunction, PhysiologicalAdultFemaleHumansMaleMiddle AgedPilot ProjectsPrevalenceQuality of LifeCalpainCAPN2 protein, humanHCRT protein, humanOrexinsAutonomic dysfunctionCalpain-2Multiple sclerosisOrexin-ASexual dysfunction

Identifiers

PMID41615500

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.