Evidence map›Paper›PMID 41615498›Full record

ReviewCancer metastasis reviews2026

The impact of genomic ancestry on tumor genomics in head and neck squamous cell carcinoma.

Madeleine Ndahayo, Anirudh Saxena, Hannah Thomas, Kathryn Hughes Barry, Daria A Gaykalova

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancer metastasis reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Madeleine NdahayoInstitute for Genome Sciences, University of Maryland School of Medicine, 670 West Baltimore Street, Baltimore, MD, USA.
Anirudh SaxenaInstitute for Genome Sciences, University of Maryland School of Medicine, 670 West Baltimore Street, Baltimore, MD, USA.
Hannah ThomasDepartment of Otorhinolaryngology-Head and Neck Surgery, Marlene & Stewart Greenebaum Comprehensive Cancer Center, University of Maryland Medical Center, Baltimore, MD, USA.
Kathryn Hughes BarryDepartment of Epidemiology and Public Health Program in Oncology, Marlene & Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA.
Daria A GaykalovaInstitute for Genome Sciences, University of Maryland School of Medicine, 670 West Baltimore Street, Baltimore, MD, USA. dgaykalova@som.umaryland.edu.

Funding

Study of Biological and Radiographic Biomarkers and Association with Ancestry and Survival Disparities in Oral Cavity Squamous Cell Carcinoma Using AI ApproachesR01DE033426 · NIDCR · UNIVERSITY OF MARYLAND BALTIMORE · PI Daria A Gaykalova, Ranee Mehra · 2024 to 2026
$2.0M
American Cancer Society RSG-21-020-01-MPCNIDCR NIH HHS R01 DE033426NIH HHS R01DE033426
6 · The paper itself

Abstract

Head and neck squamous cell carcinoma (HNSCC) exhibits significant survival disparities by ancestry. This review explores how genetic ancestry shapes the clinical and molecular features of HNSCC, providing insights into the molecular mechanisms underlying these disparities. We reveal the variation in gene expression, mutations, copy number alterations, and DNA methylation patterns between ancestral groups. These insights highlight the potential for more personalized, ancestry-informed therapies, advancing equity in cancer treatment.

Indexed as

Carcinoma, Squamous CellHead and Neck NeoplasmsSquamous Cell Carcinoma of Head and NeckDNA MethylationGenomicsHumansMutationCancer disparitiesGenetic ancestryGenomicsHead and neck squamous cell carcinomaRace

Identifiers

PMID41615498
PMCPMC12915327

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.