Evidence map›Paper›PMID 41615473›Full record

Trial reportEuropean journal of applied physiology2026

Exercise-induced bronchodilation is not impacted by beta-adrenergic receptor blockade in males or females.

Connor J Doherty, Benjamin P Thompson, Paige J Rynne, Jou-Chung Chang, Sarah A Angus, Armando J Aguero, Sean L Gartner, Paolo Dominelli

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of applied physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Connor J DohertyDepartment of Kinesiology and Health Sciences, Faculty of Health, University of Waterloo, Waterloo, ON, N2L 3G1, Canada. c7dohert@uwaterloo.ca.ORCID http://orcid.org/0000-0002-4179-9504
Benjamin P ThompsonFaculty of Kinesiology, University of Calgary, Calgary, AB, TN2 1N4, Canada.
Paige J RynneDepartment of Kinesiology and Health Sciences, Faculty of Health, University of Waterloo, Waterloo, ON, N2L 3G1, Canada.
Jou-Chung ChangFaculty of Kinesiology, University of Calgary, Calgary, AB, TN2 1N4, Canada.
Sarah A AngusDepartment of Kinesiology and Health Sciences, Faculty of Health, University of Waterloo, Waterloo, ON, N2L 3G1, Canada.
Armando J AgueroFaculty of Kinesiology, University of Calgary, Calgary, AB, TN2 1N4, Canada.
Sean L GartnerDepartment of Kinesiology and Health Sciences, Faculty of Health, University of Waterloo, Waterloo, ON, N2L 3G1, Canada.
Paolo DominelliFaculty of Kinesiology, University of Calgary, Calgary, AB, TN2 1N4, Canada.

Funding

Canada Foundation for Innovation #38432Natural Sciences and Engineering Research Council of Canada RGPIN-2019-04615
6 · The paper itself

Abstract

purposeExercise-induced bronchodilation (EIBD) is primarily driven by parasympathetic withdrawal; however, the role of sympathetic activity via beta-adrenergic receptors (β-AR) remains unclear. We sought to determine the contribution of β-AR to EIBD in healthy males and females following fatiguing single-leg knee extension exercise.

methodsFourteen healthy young adults (7 males, 7 females) completed two randomized exercise visits with or without systemic β-AR blockade (propranolol). Participants performed forced vital capacity (FVC) maneuvers before and immediately after exercise to quantify EIBD. Spirometric outcomes included forced expiratory volume in one second (FEV₁), FEV₁/FVC, peak expiratory flow (PEF), and flows at 25%, 50%, and 75% of FVC. Mean slope ratio (SR) of the maximal expiratory flow-volume (MEFV) was also quantified from the effort-independent portion of the MEFV.

resultsEIBD was confirmed by increases in FEV₁ (Δ4 ± 3% and Δ5 ± 3%) and FEV1/FVC (Δ3 ± 1% and Δ3 ± 4%) during the control condition in males and females respectively. Propranolol did not significantly alter these global markers of bronchodilation. Compared to control, propranolol significantly blunted airflow at 25% FVC (Δ0 ± 0.4L·s−1 vs. Δ0.3 ± 0.3L·s−1; p = 0.05) and 50% FVC (Δ0.1 ± 0.4L·s−1 vs. Δ0.4 ± 0.4L·s−1; p = 0.05). Females (Δ0.08 ± 0.11; p = 0.03) but not males (Δ-0.04 ± 0.07; p = 0.96) exhibited a significant increase in mean SR with propranolol.

conclusionsWhile β-AR blockade did not affect typical markers of EIBD, it impaired airflow in small airways, especially in females, suggesting sex-specific sympathetic regulation of bronchodilation. These findings highlight a nuanced role for β-AR in modulating EIBD.

Indexed as

Adrenergic beta-AntagonistsExercisePropranololReceptors, Adrenergic, betaAdultFemaleForced Expiratory VolumeHumansMaleVital CapacityYoung AdultAdrenergic beta-AntagonistsPropranololReceptors, Adrenergic, betaBeta-adrenergic receptor activityExercise-induced bronchodilationSex differencesSmall airways

Identifiers

PMID41615473

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.