Evidence map›Paper›PMID 41615472›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2026

Synthesis and integrative multimodal evaluation of cholic acid-based hydrazone conjugates: in vitro, in silico, and in vivo studies.

Muhammad Hassan Butt, Kanwal Rehman, Shagufta Kamal, Muhammad Sajid Hamid Akash

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Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Muhammad Hassan ButtDepartment of Pharmaceutical Chemistry, Government College University, Faisalabad, Pakistan.
Kanwal RehmanDepartment of Pharmacy, The Women University, Multan, Pakistan.
Shagufta KamalDepartment of Biochemistry, Government College University, Faisalabad, Pakistan.
Muhammad Sajid Hamid AkashDepartment of Pharmaceutical Chemistry, Government College University, Faisalabad, Pakistan. sajidakash@gcuf.edu.pk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cholic acid-derived hydrazones represent a promising scaffold for multifunctional drug discovery. We synthesized and characterized two novel cholic acid-based hydrazone derivatives: DFBCH (2,4-difluorobenzylidene conjugate) and MEBCH (3-methoxybenzylidene conjugate) through various spectroscopic techniques, confirming the structural integrity of the synthesized compounds, followed by their comprehensive biological evaluation. In vitro screening showed a greater antibacterial zone of inhibition of MEBCH compound as compared to DFBCH against the tested strains. MEBCH demonstrated potent antioxidant activity (IC

Indexed as

Anti-Bacterial AgentsAntioxidantsCholic AcidHydrazonesAnimalsCholinesterase InhibitorsHeLa CellsHumansMaleMicrobial Sensitivity TestsMolecular Docking SimulationRatsStructure-Activity RelationshipAnti-Bacterial AgentsAntioxidantsCholic AcidCholinesterase InhibitorsHydrazonesAntimicrobial activityAntioxidant activityBioTransformer 3.0Cholic acid–based hydrazonesCYP-mediated metabolismMolecular dockingPharmacokinetics

Identifiers

PMID41615472

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.