SynthesisGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2026
Epidemiology, biometric features and risk factors of pseudoexfoliation syndrome among cataract patients: a hospital-based study in Apulia.
Synthesis in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeto contextualize the prevalence of pseudoexfoliation syndrome (PEX) through a systematic literature review and to evaluate its epidemiology, ocular biometric features, and potential systemic associations in a hospital-based cohort of cataract patients from Southern Italy, with particular focus on the neutrophil-to-lymphocyte ratio (NLR) as a marker of systemic inflammation and surgical risk.
methodsthis study consisted of two components. First, a systematic literature review was conducted according to PRISMA principles to summarize reported PEX prevalence across different populations and geographic regions. Second, a retrospective cross-sectional cohort study was performed including consecutive cataract patients evaluated at a tertiary referral center in Apulia (Italy) between January 2024 and September 2025. Demographic data, ocular biometry, corneal parameters, systemic comorbidities, and preoperative NLR values were collected. Eye-level outcomes were analyzed using linear mixed-effects models with patient-level random intercepts, adjusting for age, sex, and eye side. Associations between NLR, biometric parameters, and surgical complications were assessed using correlation analyses and non-parametric tests.In the absence of a pre-specified primary outcome, ACD was selected a posteriori as the primary biometric endpoint.
resultsthe literature review confirmed marked heterogeneity in reported PEX prevalence worldwide, ranging from < 1% to > 30%, largely influenced by study design and population characteristics. In the cohort study, 99 of 3,736 cataract patients were diagnosed with PEX, yielding a prevalence of 2.65%. PEX patients were significantly older than non-PEX patients, with no sex predominance. After adjustment, PEX was not independently associated with axial length, anterior chamber depth, aqueous depth, lens thickness, central corneal thickness or endothelial cell density. NLR showed no significant correlation with ocular biometric parameters and did not differ between patients with and without intraoperative or postoperative complications.
conclusionPEX was relatively uncommon in this Southern Italian cohort and primarily age-related. No association was found between PEX and standard biometric features or between systemic inflammation (NLR) and surgical risk. Larger, multicenter studies integrating genetic and inflammatory markers are warranted to further elucidate PEX pathogenesis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.