Evidence map›Paper›PMID 41615410›Full record

ArticleImmunology2026

Genetic Determinants of Peanut-Specific IgG4 Levels in the Context of Sustained Oral Peanut Exposure in the LEAP Study.

Kanika Kanchan, Karen Cerosaletti, James A Perry, George DuToit, Monali Manohar, Hua Ling, Justin E Paschall, Srinath Sanda, R Sharon Chinthrajah, Gerald T Nepom and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Kanika KanchanGenomics and Precision Health Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.ORCID 0009-0003-4993-8841
Karen CerosalettiBenaroya Research Institute at Virginia Mason, Seattle, Washington, USA.
James A PerryGenomics and Precision Health Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
George DuToitThe Department of Pediatric Allergy, Division of Asthma, Allergy and Lung Biology, King's College London, and Guy's and St. Thomas' NHS Foundation Trust, London, UK.
Monali ManoharSean N. Parker Center for Allergy and Asthma Research, Stanford University, Palo Alto, California, USA.ORCID 0000-0002-1869-2645
Hua LingInstitute of Genetic Medicine, Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Justin E PaschallInstitute of Genetic Medicine, Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Srinath SandaThe Immune Tolerance Network, San Francisco, California, USA.
R Sharon ChinthrajahSean N. Parker Center for Allergy and Asthma Research, Stanford University, Palo Alto, California, USA.
Gerald T NepomBenaroya Research Institute at Virginia Mason, Seattle, Washington, USA.
Kari C NadeauDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.ORCID 0000-0002-2146-2955
Stacie M JonesDepartment of Pediatrics, Division of Allergy and Immunology, University of Arkansas for Medical Sciences and Arkansas Children's Hospital, Little Rock, Arkansas, USA.ORCID 0000-0003-3491-4815
Gideon LackThe Department of Pediatric Allergy, Division of Asthma, Allergy and Lung Biology, King's College London, and Guy's and St. Thomas' NHS Foundation Trust, London, UK.
Ingo RuczinskiDepartment of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Rasika A MathiasGenomics and Precision Health Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.ORCID 0000-0002-2282-9042

Funding

Immune Tolerance Network UM1 2023 SupplementUM1AI109565 · NIAID · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI Mark S Anderson, Jane Hoyt Buckner · 2014 to 2026
$451.6M
Integrative-omics and Systems Biology across the atopic marchZIAAI001381 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI MATHIAS, RASIKA · 2024 to 2025
$3.7M
Crown Family PhilanthropiesEnd Allergies TogetherFood Allergy Research & Education Center of ExcellenceImmune Tolerance Network UM1AI109565Immune Tolerance Network UM2AI117870Intramural NIH HHS ZIA AI001381Myra Reinhard Family FoundationNational Center for Research Resources supported Clinical Translational Science Awards, and Clinical Research Centers TR000067National Center for Research Resources supported Clinical Translational Science Awards, and Clinical Research Centers TR000424National Center for Research Resources supported Clinical Translational Science Awards, and Clinical Research Centers TR001111National Center for Research Resources supported Clinical Translational Science Awards, and Clinical Research Centers TR003107National Center for Research Resources supported Clinical Translational Science Awards, and Clinical Research Centers TR003142National Institute of Allergy and Infectious Diseases U19AI104209NIAID NIH HHS UM1 AI109565Sean N. Parker Center for Allergy and Asthma Research at Stanford UniversityTripAdvisor Charitable Foundation
6 · The paper itself

Abstract

In the Learning Early About Peanut Allergy (LEAP) study, participants in the peanut consumption group, at 60 months of age, had higher levels of peanut-specific IgG4 (psIgG4), a biomarker of immune modulation, compared to those in the peanut-avoidance group. We investigated the genetic determinants of psIgG4 among participants who consumed peanuts. Using whole-genome sequencing data, we performed a genome-wide association study (GWAS) for psIgG4 in the LEAP peanut consumption group participants (N = 267). We generated a cumulative genetic score from the identified loci and evaluated its association with psIgG4 levels in LEAP. The association was then assessed for replication in two independent peanut oral immunotherapy (PnOIT) trials, IMPACT and POISED. We identified 45 variants that reached suggestive significance (p < 1 × 10

Indexed as

AllergensArachisImmunoglobulin GPeanut HypersensitivityAdministration, OralChild, PreschoolDesensitization, ImmunologicFemaleGene-Environment InteractionGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansInfantMalePolymorphism, Single NucleotideAllergensImmunoglobulin Gepithelial barrier functiongenetic scoreimmunotherapypsIgG4tolerance

Identifiers

PMID41615410
PMCPMC13135883

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.