ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2026
A Socio-ecological Analysis of Factors Influencing the Perceived Value of Multicancer Early Detection Testing in the United States.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundMulticancer early detection (MCED) tests represent a novel advancement in cancer diagnostics, detecting multiple cancer types through a single blood draw. Understanding factors shaping individual receptivity is crucial for equitable implementation.
methodsUsing a socio-ecological framework, we analyzed nationally representative data from the 2024 Health Information National Trends Survey to examine predictors of perceived MCED value across proximal, intermediate, and distal levels. Survey-weighted logistic regressions estimated adjusted odds ratios (aOR) with 95% confidence intervals (CI).
resultsA total of 7,208 adults were included; 73.6% rated MCED testing as moderately to highly valuable. Adults aged 40 to 44 years (aOR = 2.23; 95% CI, 1.33-3.75; P = 0.003) and ≥45 years (aOR = 2.56; 95% CI, 1.80-3.65) had more than twice the odds of valuing MCED testing versus those aged 18 to 34 years. Hispanic (aOR = 2; 95% CI, 1.34-3) and non-Hispanic Black respondents (aOR = 1.86; 95% CI, 1.22-2.84) reported significantly greater receptivity than non-Hispanic Whites. Greater trust in the healthcare system (aOR = 1.55; 95% CI, 1.16-2.06), reported healthcare discrimination (aOR = 1.63; 95% CI, 1.04-2.54), and longer wait times for test results (aOR = 1.44; 95% CI, 1.05-1.98) were associated with higher perceived MCED value.
conclusionsMCED testing receptivity seems to be influenced by sociodemographic, psychosocial, and structural factors. Greater receptivity among Black/Hispanic individuals and those reporting discrimination may reflect "protective vigilance" against systemic barriers. IMPACT: Our findings highlight opportunities for targeted interventions promoting equitable MCED uptake through trust-building and follow-up across populations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.