ArticleArchives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists2026
Quality of Life, Self-Reported Cognitive Difficulties, and Performance-Based Cognitive Problems in Multiple Sclerosis: What's Sleep Got to Do With It?
Article in Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveExamine group differences between people with multiple sclerosis (PwMS) with poor and adequate sleep quality on cognition (performance-based and self-reported difficulties) and examine the contribution of sleep quality on quality of life (QoL).
methodCross-sectional study of 97 PwMS. Two groups were created from a sleep quality composite: poor (n = 22) and adequate (n = 72) sleep quality. Seven domains from the Functional Assessment of Multiple Sclerosis (FAMS) assessed quality of life. A dichotomous (yes/no) item on the Sleep Habits Questionnaire assessed self-reported cognitive difficulties. Performance-based cognition was measured with a composite of mean neuropsychological performance and 2 intraindividual variability (IIV) indices. Two mulitavariate analyses of variance examined group differences on cognition and QoL. A chi-square test compared the proportion of PwMS with poor versus adequate sleep quality who self-reported cognitive difficulties. Follow-up hierarchical linear regressions were conducted to account for disease progression, fatigue, and depression.
resultsPwMS with poor and adequate sleep quality did not significantly differ in terms of performance-based cognitive functioning. A significantly greater proportion of PwMS with poor sleep quality reported that sleep patterns affected their cognitive abilities (86.36%) compared to those with adequate sleep quality (40.28%), χ2(1, N = 94) = 14.32, p < .001, φ = -.39. After accounting for disease progression, depression, and fatigue, sleep quality significantly predicted Symptoms QoL, R2 =.04, ΔF(1,88) = 4.72, p = .03, and Fatigue QoL, R2 = .05, ΔF(1,89) = 5.64, p = .02.
conclusionsPoor sleep quality was not associated with performance-based cognitive functioning but was associated with greater self-reported cognitive difficulties. After accounting for disease progression, depression, and fatigue, poor sleep quality was significantly predictive of both Symptoms and Fatigue QoL.
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