ArticleArchives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists2026
Apathy and Depression Impact on Cognitive Decline: Neuropsychological Specificities across Neurodegenerative Diseases.
Article in Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Apathy in dementia with Lewy bodies: Frequency, correlates, and impact on patient and caregiver experiences.Parkinsonism & related disorders · 2026Article
- Apathy-depression overlap: unmasking hidden disability profiles in multiple sclerosis.Frontiers in neurology · 2026Article
- Beyond cognition in post-stroke cognitive impairment: neuropsychiatric symptoms and stroke-specific cognitive screening.Cerebral circulation - cognition and behavior · 2026Article
- The Versatile Roles of Exosomes in Neurodegenerative Disorders: From Pathological Mechanism and Diagnostic Biomarkers to Therapeutic Application.Drug design, development and therapy · 2026Review
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveApathy is a common symptom across neurodegenerative diseases with origins still debated. "Vascular apathy hypothesis" by Van der Mast suggests vascular pathologies precede apathy. Other evidence points to dysfunction in dopamine pathways, driving apathy by impairing goal-directed behaviour. The impact of apathy on cognitive decline and autonomy, particularly with coexisting depression, remains unclear. This cross-sectional study aimed to (1) characterize apathy in vascular dementia, Parkinson's disease (PD), and Mild Cognitive Impairment-Alzheimer Disease (MCI-AD) regarding incidence, severity, and cognitive specificity; (2) differentiate effects of apathy and depression on cognitive impairment and daily autonomy (Activities of Daily Living [ADL]).
methodFifty-three patients underwent neuropsychological testing and completed the Geriatric Depression Scale, Starkstein's Apathy Scale, and ADL questionnaire at a clinical neuropsychology outpatient setting in Milan.
results56% patients had cardiovascular pathologies, 20% had PD, and 22% had MCI-AD. Neither prevalence nor severity of apathy or depression differed significantly across diseases. Hierarchical regression showed apathy predicted language initiative controlling for depression (R2 = 0.249; F(2) = 4.144; p = .028), and inversely correlated with working memory, language and frontal functioning, while depression predicted autonomy controlling for apathy (R2 = 0.234; F (2) = 3.821; p = .036).
conclusionsApathy is prevalent across different neurodegenerative diseases and exacerbates specific cognitive impairments. Distinguishing vascular apathy from other forms remains challenging.
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