Evidence map›Paper›PMID 41615334›Full record

ArticleClinical transplantation2026

Postoperative Atrial Arrhythmias After Lung Transplantation: A Single Center Analysis of Risk Factors, Management, and Outcomes.

Daniel M Chen, Ambalavanan Arunachalam, Graham Peigh, Bradley P Knight, Chitaru Kurihara, Mrinalini Venkata Subramani, Catherine Myers, Alan Betensley, Krishnan Warrior, Bradford C Bemiss and 2 more

Abstract read
In one paragraph

Article in Clinical transplantation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Daniel M ChenFeinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.ORCID https://orcid.org/0000-0003-3257-1484
Ambalavanan ArunachalamFeinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.ORCID https://orcid.org/0000-0002-0363-7889
Graham PeighFeinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.ORCID https://orcid.org/0000-0002-2388-8896
Bradley P KnightFeinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.ORCID https://orcid.org/0000-0002-2129-0401
Chitaru KuriharaFeinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.ORCID https://orcid.org/0000-0003-3536-4675
Mrinalini Venkata SubramaniFeinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.ORCID https://orcid.org/0000-0003-3545-2747
Catherine MyersFeinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.ORCID https://orcid.org/0000-0002-3761-153X
Alan BetensleyFeinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.ORCID https://orcid.org/0000-0002-5538-6831
Krishnan WarriorFeinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.ORCID https://orcid.org/0000-0002-4157-5500
Bradford C BemissFeinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.ORCID https://orcid.org/0000-0003-2877-4174
Amanda KamarFeinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.ORCID https://orcid.org/0009-0001-5395-345X
Mohamed Al-KazazFeinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.ORCID https://orcid.org/0009-0003-9357-0175

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPostoperative atrial arrhythmia (POAA) is common after lung transplant, but data on its implications and management are limited. This study assessed POAA incidence and timing, its association with mortality and rehospitalizations, and outcomes related to postoperative beta-blocker use.

methodsWe retrospectively studied 233 adult lung transplant patients at Northwestern Memorial Hospital (2014-2024) without prior atrial arrhythmia. POAA, defined as atrial fibrillation or flutter, was confirmed by ECG or ambulatory monitoring. Multivariable logistic and Cox regression models evaluated predictors and outcomes, adjusting for covariates.

resultsPOAA occurred in 69/233 patients (29.6%) and was associated with higher mortality (HR3.09, 95%CI [1.57-6.08]). Among these, 18/69 (26.1%) developed POAA after the index hospitalization at median 216 days post-transplant, also associated with higher mortality (HR4.37, 95%CI [1.90-10.06]). Additionally, 10/69 (14.5%) required emergency visits or hospitalization specifically for arrhythmia management, and 66.6% underwent additional rhythm control (2.9% cardioversion, 46.4% anti-arrhythmic drug, 17.4% both). Postoperative beta-blocker use was associated with 73% less POAA (HR0.27, 95%CI [0.09-0.80]).

conclusionPOAA was common and clinically significant after lung transplant, associated with substantially higher adjusted mortality even when occurring after index hospitalization. We report for the first time that POAA was frequently associated with emergency visits or rehospitalization for arrhythmia, highlighting its clinical burden well beyond the perioperative period. Postoperative beta-blocker use was associated with markedly less POAA, a novel finding suggesting a potential prophylactic role. Overall, these findings challenge the traditional view of POAA as benign and highlight the need for tailored, evidence-based guidelines in this high-risk population.

Indexed as

Atrial FibrillationAtrial FlutterLung TransplantationPostoperative ComplicationsAdrenergic beta-AntagonistsAdultFemaleFollow-Up StudiesHumansIncidenceMaleMiddle AgedPrognosisRetrospective StudiesRisk FactorsSurvival RateAdrenergic beta-Antagonistsanticoagulationarrhythmia‐related hospitalizationbeta‐blockerlate atrial arrhythmiamortalitypulmonary arterial hypertensionstroke

Identifiers

PMID41615334
PMCPMC12857598

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.