SynthesisActa ophthalmologica2026
Prognostic factors of optical coherence tomography angiography in intermediate and advanced primary open-angle glaucoma: A systematic review and meta-analysis.
Synthesis in Acta ophthalmologica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Conventional optical coherence tomography (OCT) has a floor effect in patients with severe visual field loss, such as seen in advanced primary open-angle glaucoma (POAG). OCT angiography (OCTA) does not suffer from such a floor effect. However, which OCTA parameters are most useful for monitoring longitudinal progression is unclear. We conducted a systematic review and meta-analysis to investigate the clinical use of OCTA in monitoring the progression of intermediate and advanced POAG by searching four databases (Medline, Embase, Web of Science and Cochrane Database of Systematic Reviews) for longitudinal studies on POAG and OCTA. For each meta-analysed OCTA parameter, we calculated a pooled effect estimate with a 95% confidence interval (95% CI). Parameters that could not be meta-analysed were compared narratively. A total of 18 studies were included in the systematic review and seven in the meta-analyses. In the meta-analyses, a lower baseline peripapillary vessel density (VD) significantly increased the risk of visual field (VF) progression (HR [95% CI]: 1.05 [1.02, 1.07] for each percentage decrease in peripapillary VD per year). Baseline parafoveal VD and risk of VF progression showed no significant association. The inferior hemifield foveal avascular zone parameters and the presence of peripapillary choroidal microvascular dropout were significantly associated with the risk of VF progression in the systematic review. Peripapillary VD may be a useful predictor of VF progression in intermediate and advanced glaucoma patients. Although FAZ and MvD also seem to be potential predictors, longitudinal studies on advanced POAG are limited and heterogeneous, highlighting the need for more consistent and comprehensive research.
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