Evidence map›Paper›PMID 41615185›Full record

ArticleJournal of virology2026

RNA helicase DDX5 regulates the translation and genomic replication of foot-and-mouth disease virus.

Jin'en Wu, Sahibzada Waheed Abdullah, Pinghua Li, Xuefei Wang, Mei Ren, Yuanyuan Huang, Xianglong Guo, Shiqi Sun, Huichen Guo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jin'en WuState Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.ORCID 0000-0002-9409-9552
Sahibzada Waheed AbdullahLivestock and Dairy Development (Extension) Department, Government of Khyber Pakhtunkhwa, Peshawar, Pakistan.
Pinghua LiState Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.
Xuefei WangState Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.
Mei RenState Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.
Yuanyuan HuangState Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.
Xianglong GuoState Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.
Shiqi SunState Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.
Huichen GuoState Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.ORCID 0000-0003-0539-497X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The internal ribosome entry site (IRES) is a cis-acting structural element found in many viral mRNAs, which mediates cap-independent translation by recruiting various RNA-binding proteins and IRES trans-acting factors (ITAFs). Foot-and-mouth disease virus (FMDV), a significant member of the IMPORTANCE: Picornaviruses have evolved various strategies to compete and dominate host protein synthesis machinery, often bypassing cap-dependent mRNA translation. Foot-and-mouth disease virus (FMDV), a highly contagious member of the

Indexed as

DEAD-box RNA HelicasesFoot-and-Mouth Disease VirusProtein BiosynthesisRNA ReplicationVirus Replication3' Untranslated RegionsAnimalsCell LineFoot-and-Mouth DiseaseGenome, ViralHumansInternal Ribosome Entry SitesRNA-Dependent RNA PolymeraseRNA, ViralViral Nonstructural ProteinsViral Proteins3ABC protein, virus3' Untranslated RegionsDdx5 protein, humanDEAD-box RNA HelicasesInternal Ribosome Entry SitesRNA-Dependent RNA PolymeraseRNA, ViralViral Nonstructural ProteinsViral ProteinsDDX5foot-and-mouth disease virus (FMDV)internal ribosome entry site (IRES)IRES-driven translationreplication

Identifiers

PMID41615185
PMCPMC13011465

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.