Evidence map›Paper›PMID 41615159›Full record

ArticlemBio2026

Ligand binding drives proteolysis of the SmcR master transcription factor and controls quorum sensing-state transitions in

Tanmaya A Rasal, Caleb P Mallery, Biqing Liang, Matthew W Brockley, Chelsea A Simpson, Abigail D Padgett, Logan J Geyman, Finley J Andrew, Laura C Brown, Jon E Paczkowski and 1 more

Abstract read
In one paragraph

Article in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Tanmaya A RasalDepartment of Biology, Indiana University, Bloomington, Indiana, USA.ORCID 0000-0002-4132-1551
Caleb P MalleryDepartment of Biomedical Sciences, University at Albany, Albany, New York, USA.ORCID 0009-0008-1114-513X
Biqing LiangDepartment of Biomedical Sciences, University at Albany, Albany, New York, USA.
Matthew W BrockleyDivision of Genetics, Wadsworth Center, New York State Department of Health, Albany, New York, USA.
Chelsea A SimpsonDepartment of Biology, Indiana University, Bloomington, Indiana, USA.
Abigail D PadgettDepartment of Biology, Indiana University, Bloomington, Indiana, USA.
Logan J GeymanDepartment of Biology, Indiana University, Bloomington, Indiana, USA.
Finley J AndrewRyan White Center for Pediatric Infectious Diseases and Global Health, Herman B. Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Laura C BrownDepartment of Chemistry, Indiana University, Bloomington, Indiana, USA.
Jon E PaczkowskiDepartment of Biomedical Sciences, University at Albany, Albany, New York, USA.ORCID 0000-0002-8286-3808
Julia C van KesselDepartment of Biology, Indiana University, Bloomington, Indiana, USA.ORCID 0000-0002-1612-2403

Funding

Training and OutreachP30GM124166 · NIGMS · CORNELL UNIVERSITY · PI RICHARD A. CERIONE · 2019 to 2026
$28.3M
Quorum sensing regulation of bacterial developmentR35GM124698 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI Julia C. van Kessel · 2017 to 2026
$4.1M
RNA Science and Technology in Health and DiseaseT32GM132066 · NIGMS · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI Thomas J Begley · 2019 to 2026
$1.8M
A chemical strategy for inhibiting Vibrio quorum sensing and virulence.R56AI187447 · NIAID · TRUSTEES OF INDIANA UNIVERSITY · PI PACZKOWSKI, JON E, VAN KESSEL, JULIA C. · 2025 to 2025
$504k
National Science Foundation DBI-175710National Science Foundation GRFPNIAID NIH HHS R56 AI187447NIGMS NIH HHS P30 GM124166NIGMS NIH HHS R35 GM124698NIH HHS 1R56AI187447-01NIH HHS R01GM14436101NIH HHS R35GM124698NIH HHS T32GM132066
6 · The paper itself

Abstract

In

Indexed as

Bacterial ProteinsQuorum SensingTranscription FactorsVibrioGene Expression Regulation, BacterialLigandsProtein BindingProteolysisTrans-ActivatorsVibrio vulnificusBacterial ProteinsLigandssmcR protein, Vibrio vulnificusTrans-ActivatorsTranscription Factorsproteasequorum sensingquorum sensing inhibitorsSmcRthiophenesulfonamidesVibrioVibrio vulnificus

Identifiers

PMID41615159
PMCPMC12977469

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.