Evidence map›Paper›PMID 41614949›Full record

ArticleCurrent issues in molecular biology2026

Impact of Melatonin on Sepsis-Associated Acute Kidney Injury in Rat Model of Lipopolysaccharide Endotoxemia.

Milan Potić, Ivan Ignjatović, Dragoslav Bašić, Ljubomir Dinić, Aleksandar Skakić, Zoran Damnjanović, Nebojša Jovanović, Milica Mitić, Dušan Sokolović

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In one paragraph

Article in Current issues in molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Milan PotićFaculty of Medicine, University of Niš, 18000 Niš, Serbia.
Ivan IgnjatovićFaculty of Medicine, University of Niš, 18000 Niš, Serbia.
Dragoslav BašićFaculty of Medicine, University of Niš, 18000 Niš, Serbia.
Ljubomir DinićFaculty of Medicine, University of Niš, 18000 Niš, Serbia.
Aleksandar SkakićFaculty of Medicine, University of Niš, 18000 Niš, Serbia.
Zoran DamnjanovićFaculty of Medicine, University of Niš, 18000 Niš, Serbia.
Nebojša JovanovićCenter for Gynecology and Human Reproduction, Medical Military Academy, 11000 Belgrade, Serbia.
Milica MitićCenter for Pathology and Pathological Anatomy, University Clinical Center Niš, 18000 Niš, Serbia.ORCID 0000-0002-3301-3970
Dušan SokolovićFaculty of Medicine, University of Niš, 18000 Niš, Serbia.ORCID 0000-0001-6586-6428

Funding

Ministry of Education, Science, and Technological Development of the Republic of Serbia 451-03-137/2025-03/200113
6 · The paper itself

Abstract

Sepsis-associated acute kidney injury (S-AKI) is a frequent and life-threatening condition, characterized by rapid functional decline, which is followed by intense inflammation and tissue injury. Experimental lipopolysaccharide (LPS)-induced sepsis reproduces functional and morphological features of human S-AKI and enables investigation of melatonin which has numerous beneficial properties, such as antioxidant properties. In this study, the effects of melatonin (50 mg/kg) on kidney dysfunction, oxidative damage, inflammation, apoptosis, and histopathological alterations in a rat model of S-AKI induced by LPS application (10 mg/kg) were studied. Acute LPS exposure caused statistically significant (

Indexed as

apoptosiscaspaseinflammationkidneylipopolysaccharidemelatonin

Identifiers

PMID41614949
PMCPMC12839939

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.