Evidence map›Paper›PMID 41614923›Full record

ArticleCurrent issues in molecular biology2026

Gene Expression Profiles of Melanocytes Over-Expressing miR-5110 in Alpaca.

Shanshan Yang, Dingxing Jiao, Fengsai Li, Xuqi Wang, Tao Song, Lili Wang, Ping Rui, Zengjun Ma

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current issues in molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shanshan YangCollege of Animal Science and Technology, Hebei Normal University of Science and Technology, Qinhuangdao 066000, China.
Dingxing JiaoCollege of Animal Science and Technology, Hebei Normal University of Science and Technology, Qinhuangdao 066000, China.
Fengsai LiCollege of Animal Science and Technology, Hebei Normal University of Science and Technology, Qinhuangdao 066000, China.
Xuqi WangCollege of Animal Science and Technology, Hebei Normal University of Science and Technology, Qinhuangdao 066000, China.
Tao SongCollege of Animal Science and Technology, Hebei Normal University of Science and Technology, Qinhuangdao 066000, China.ORCID 0000-0002-9730-7855
Lili WangCollege of Animal Science and Technology, Hebei Normal University of Science and Technology, Qinhuangdao 066000, China.
Ping RuiCollege of Animal Science and Technology, Hebei Normal University of Science and Technology, Qinhuangdao 066000, China.
Zengjun MaCollege of Animal Science and Technology, Hebei Normal University of Science and Technology, Qinhuangdao 066000, China.ORCID 0000-0003-4379-7534

Funding

Special Project for Basic Scientific Research of Provincial Universities 2023JK02the Science and Technology Research Project of colleges and universities in Hebei province QN2026326the Scientific Research Fund of the Hebei Normal Unixersity of Science and Technology 2023YB004
6 · The paper itself

Abstract

Previous studies have shown that miR-5110 regulates pigmentation by cotargeting melanophilin (MLPH) and WNT family member 1 (WNT1). In order to find the possible molecular mechanism for pigmentation, we examined the mRNA expression profiles in melanocytes of alpaca transfected with miR-5110, inhibitor or negative control (NC) plasmids using high-throughput RNA sequencing. The results showed that a total of 91,976 unigenes were assembled from the reads, among which 13,262 had sequence sizes greater than 2000 nucleotides. According to the KEGG pathway analysis, four pathways related to melanogenesis, the MAPK signaling pathway, Wnt signaling pathway, and cAMP signaling pathway were identified. Compared to the NC, 162 gene were upregulated and 41 genes were downregulated in melanocytes over expressed by miR-5110. The differential expressions of mRNAs Dickkopf 3 (

Indexed as

differential expressiongene expression profileKitlMAPKAPK3melanogenesismiR-5110

Identifiers

PMID41614923
PMCPMC12840492

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.