Evidence map›Paper›PMID 41614836›Full record

ArticleCurrent issues in molecular biology2025

Elevated Allele Frequency and Male-Predominance of a Common

Katja Seipel, Alina Mena, Pinar Horum, Michele Hoffmann, Inna Shaforostova, Ulrike Bacher, Thomas Pabst

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current issues in molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Katja SeipelDepartment of Medical Oncology, Inselspital, University Hospital Bern, University of Bern, 3010 Bern, Switzerland.ORCID 0000-0003-3128-1573
Alina MenaDepartment of Medical Oncology, Inselspital, University Hospital Bern, University of Bern, 3010 Bern, Switzerland.
Pinar HorumDepartment of Medical Oncology, Inselspital, University Hospital Bern, University of Bern, 3010 Bern, Switzerland.
Michele HoffmannDepartment of Medical Oncology, Inselspital, University Hospital Bern, University of Bern, 3010 Bern, Switzerland.
Inna ShaforostovaDepartment of Medical Oncology, Inselspital, University Hospital Bern, University of Bern, 3010 Bern, Switzerland.
Ulrike BacherDepartment of Hematology, University Hospital Bern, 3010 Bern, Switzerland.ORCID 0000-0001-8771-947X
Thomas PabstDepartment of Medical Oncology, Inselspital, University Hospital Bern, University of Bern, 3010 Bern, Switzerland.ORCID 0000-0002-6055-5257

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The incidence of multiple myeloma is higher in males. The underlying mechanisms may be related to differences in immune system orchestration in males and females. LAG3 and CTLA4 are immune checkpoint proteins and inhibitory regulators of T cells. Here, we analyzed the prevalence of the common

Indexed as

autologous stem cell transplantation (ASCT)cytotoxic T-lymphocyte associated protein 4 (CTLA4)genetic risklymphocyte activation gene 3 (LAG3)minor allele frequency (MAF)multiple myeloma (MM)single nucleotide polymorphism (SNP)

Identifiers

PMID41614836
PMCPMC12839972

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.