Advancing Drug Repurposing for Rheumatoid Arthritis: Integrating Protein-Protein Interaction, Molecular Docking, and Dynamics Simulations for Targeted Therapeutic Approaches.

Krishna Swaroop Akey, Bharat Kumar Reddy Sanapalli, Dilep Kumar Sigalapalli, Ramya Tokala, Vidyasrilekha Sanapalli

Abstract read

In one paragraph

Article in Current issues in molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

Integrated Network Pharmacology and Molecular Dynamics Reveal Luteolin fromInternational journal of molecular sciences · 2026
Article
Integrating Network Pharmacology and Experimental Validation Reveals EGFR/PI3K/Akt Axis Mediates Ibrutinib-Induced Cardiotoxicity.Dose-response : a publication of International Hormesis Society
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Krishna Swaroop AkeyDepartment of Pharmaceutical Chemistry, Shri Vile Parle Kelavani Mandal's College of Pharmacy, Shirpur 425421, MH, India.ORCID 0000-0003-2696-4193

Bharat Kumar Reddy SanapalliDepartment of Pharmacology, School of Pharmacy & Technology Management, SVKM's Narsee Monjee Institute of Management Studies (NMIMS) Deemed-to-be-University, Jadcherla 509301, TS, India.ORCID 0000-0002-9162-5553

Dilep Kumar SigalapalliDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0002-7286-0128

Ramya TokalaDepartment of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.ORCID 0000-0002-7532-9578

Vidyasrilekha SanapalliDepartment of Pharmaceutical Chemistry, School of Pharmacy & Technology Management, SVKM's Narsee Monjee Institute of Management Studies (NMIMS) Deemed-to-be-University, Jadcherla 509301, TS, India.ORCID 0000-0001-8298-1161

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

drug repurposingMD simulationmolecular dockingnetwork pharmacologyrheumatoid arthritis

Identifiers

PMID41614803

DOI10.3390/cimb47121039

PMCPMC12731883

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.