ReviewCurrent issues in molecular biology2025
Mechanistic Insights into the Wound Healing Activity of Plant Species in Diabetic Ulcers.
Review in Current issues in molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Multifunctional Hydrogels for Diabetic Wound Healing: Design Strategies and Microenvironmental Remodeling Mechanisms.Gels (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Diabetic foot ulcers represent a major complication driven by chronic inflammation, oxidative stress, impaired angiogenesis, and defective extracellular matrix remodeling. This integrative review synthesizes mechanistic evidence from 51 preclinical studies evaluating plant-derived interventions in diabetic animal models. Database searches (PubMed, Embase, Scopus) identified species modulating discrete molecular targets across healing phases. In the inflammatory phase, extracts suppressed NF-κB-dependent cytokine production (IL-1β, TNF-α, IL-6), reduced oxidative stress via Nrf2/HO-1 activation, and disrupted AGE-RAGE signaling, facilitating neutrophil resolution and macrophage reprogramming. During proliferation, interventions upregulated angiogenic factors (VEGF, bFGF, IGF-1) through ERK1/2 and PI3K/Akt-eNOS pathways, stimulated fibroblast proliferation, and enhanced collagen deposition. In the remodeling phase, extracts improved tensile strength by modulating MMP-2/9 and TIMP-2 balance, promoting type I collagen maturation and organized fiber architecture. Polyphenol-rich species (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.