Evidence map›Paper›PMID 41614712›Full record

ArticleOrganic letters2026

A Three-Layer Transformation Strategy toward Functionalized Fused Hydantoins and Diketopiperazines.

Maria-Aikaterini Giannakaki, Marios Zingiridis, Konstantinos G Froudas, Constantinos G Neochoritis

Abstract read
In one paragraph

Article in Organic letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Maria-Aikaterini GiannakakiDepartment of Chemistry, University of Crete, Heraklion 700 13, Greece.
Marios ZingiridisDepartment of Chemistry, University of Crete, Heraklion 700 13, Greece.ORCID 0009-0008-1150-2926
Konstantinos G FroudasDepartment of Chemistry, University of Crete, Heraklion 700 13, Greece.
Constantinos G NeochoritisDepartment of Chemistry, University of Crete, Heraklion 700 13, Greece.ORCID 0000-0001-5098-5504

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present mAUCy (modified Asinger-Ugi cyclization), a scalable three-layer strategy enabling rapid synthesis of diverse thiazolo hydantoins and diketopiperazines. Beginning from 3-thiazolines via a modified Asinger reaction, followed by an Ugi-Joullié multicomponent reaction and base-induced annulation, the method delivers complex compounds in less than 3 h. Operable on a multigram scale without chromatography, it allows telescoped one-pot processing, a broad substrate scope, and late-stage modifications. Single-crystal analysis confirmed the scaffold structures.

Identifiers

PMID41614712
PMCPMC12910713

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.