Evidence map›Paper›PMID 41614682›Full record

ArticleACS chemical biology2026

Integrated Metabolomic and Genomic Insights into Amino Acid Incorporation Within the Hybrid Polyketide-Alkaloid Antibiotic TLN-05220.

Jennifer L Cordoza, Rachel A Johnson, Andrew E Whiteley, Calista A Horta, Jayna C Nicholas, Diana M Owen, Laura Rodriguez-Velandia, Gordon T Luu, Valentina Z Petukhova, Jackson T Calhoun and 3 more

Abstract read
In one paragraph

Article in ACS chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Jennifer L CordozaUniversity of California, Santa Cruz, Santa Cruz, California 95064-1077, United States.ORCID 0000-0001-8589-9200
Rachel A JohnsonCalifornia Polytechnic State University, San Luis Obispo, San Luis Obispo, California 93407, United States.ORCID 0000-0003-1958-2218
Andrew E WhiteleyCalifornia Polytechnic State University, San Luis Obispo, San Luis Obispo, California 93407, United States.ORCID 0000-0002-0165-8395
Calista A HortaCalifornia Polytechnic State University, San Luis Obispo, San Luis Obispo, California 93407, United States.ORCID 0000-0002-2036-6400
Jayna C NicholasCalifornia Polytechnic State University, San Luis Obispo, San Luis Obispo, California 93407, United States.
Diana M OwenCalifornia Polytechnic State University, San Luis Obispo, San Luis Obispo, California 93407, United States.
Laura Rodriguez-VelandiaUniversity of California, Santa Cruz, Santa Cruz, California 95064-1077, United States.
Gordon T LuuUniversity of California, Santa Cruz, Santa Cruz, California 95064-1077, United States.ORCID 0000-0001-5937-7855
Valentina Z PetukhovaUniversity of Illinois Chicago, Chicago, Illinois 60612-7229, United States.ORCID 0009-0008-9682-822X
Jackson T CalhounUniversity of California, Santa Cruz, Santa Cruz, California 95064-1077, United States.
Laura M SanchezUniversity of California, Santa Cruz, Santa Cruz, California 95064-1077, United States.ORCID 0000-0001-9223-7977
Shaun M K McKinnieUniversity of California, Santa Cruz, Santa Cruz, California 95064-1077, United States.ORCID 0000-0001-6776-6455
Katharine R WattsCalifornia Polytechnic State University, San Luis Obispo, San Luis Obispo, California 93407, United States.ORCID 0000-0002-6421-8370

Funding

MALDI-TOF MS/IDBac to discover antibiotics from the Great Lakes sponge microbiomeR01GM125943 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MURPHY, BRIAN THACHER, SANCHEZ, LAURA MARGARET · 2018 to 2021
$2.1M
NIGMS NIH HHS R01 GM125943
6 · The paper itself

Abstract

Actinobacteria are a rich source of bioactive compounds and unique biosynthetic chemistry.

Indexed as

AlkaloidsAmino AcidsAnti-Bacterial AgentsMetabolomicsMicromonosporaPolyketidesGenomicsMultigene FamilyAlkaloidsAmino AcidsAnti-Bacterial AgentsPolyketides

Identifiers

PMID41614682
PMCPMC12983988

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.