Evidence map›Paper›PMID 41614632›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Postoperative Stress Accelerates Atherosclerosis Through Inflammatory Remodeling of the HDL Proteome and Impaired Reverse Cholesterol Transport.

Dominique M Boucher, Victoria Lorant, Valerie Rochon, Abigail Carter, Cameron Stotts, My-Anh Nguyen, Thomas Laval, Christina Emerton, Nathan Joyce, Nysa Vinayak and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Dominique M BoucherDepartment of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.ORCID https://orcid.org/0000-0003-2223-0117
Victoria LorantDepartment of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.ORCID https://orcid.org/0009-0009-4762-1465
Valerie RochonDepartment of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.
Abigail CarterSaha Cardiovascular Research Center and Department of Physiology, University of Kentucky, Lexington, Kentucky, USA.
Cameron StottsDepartment of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.ORCID https://orcid.org/0000-0001-5321-6145
My-Anh NguyenDepartment of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.
Thomas LavalDepartment of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.
Christina EmertonUniversity of Ottawa Heart Institute, Ottawa, Ontario, Canada.
Nathan JoyceDepartment of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.ORCID https://orcid.org/0009-0000-1270-5823
Nysa VinayakUniversity of Ottawa Heart Institute, Ottawa, Ontario, Canada.
Marlena ScaffidiDepartment of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.
David CookCancer Therapeutics Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.ORCID https://orcid.org/0000-0001-7639-6724
Katey J RaynerDepartment of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.ORCID https://orcid.org/0000-0001-6230-426X
Rebecca C AuerDepartment of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.ORCID https://orcid.org/0000-0002-3617-0015
Scott M GordonSaha Cardiovascular Research Center and Department of Physiology, University of Kentucky, Lexington, Kentucky, USA.ORCID https://orcid.org/0000-0001-9532-032X
Mireille I OuimetDepartment of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.ORCID https://orcid.org/0000-0002-6831-5047

Funding

Functional Interactions Between Lipoproteins and Protease Inhibitors in AtherosclerosisR01HL171111 · NHLBI · UNIVERSITY OF KENTUCKY · PI Scott M Gordon · 2024 to 2026
$1.9M
Canada Graduate Scholarship-Master's ProgramCanadian Institutes for Health Research PJT-541283Heart and Stroke Foundation of CanadaNHLBI NIH HHS R01 HL171111NIH HHS R01HL171111UOHI Endowed FellowshipVanier Canada Graduate Scholarship
6 · The paper itself

Abstract

Over 10 million patients undergoing non-cardiac surgery each year face major cardiovascular complications within 30 days, many due to destabilized atherosclerotic plaques. Reverse cholesterol transport (RCT), driven by HDL and Apoa1, protects against plaque progression, but the effects of surgical inflammation on this pathway remain unclear. Using an abdominal laparotomy model in ApoE

Indexed as

AtherosclerosisCholesterolInflammationLipoproteins, HDLPostoperative ComplicationsProteomeAnimalsApolipoprotein A-IBiological TransportDisease Models, AnimalFoam CellsHumansMaleMiceMice, Inbred C57BLApolipoprotein A-ICholesterolLipoproteins, HDLProteomeacute phase responseatherosclerosisHDLreverse cholesterol transportsurgery

Identifiers

PMID41614632
PMCPMC13159145

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.