Evidence map›Paper›PMID 41614571›Full record

ArticleAnnals of medicine2026

Regional homogeneity alterations reflect pain and emotional dysregulation in adenomyosis.

Wenjiang Wei, Yanying Chen, Kelei Hua, Bin Xia, Rujin Li, Weizhao Lin, Zichao Chen, Wenqing Xiao, Kanghui Yu, Yi Yin and 2 more

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PubMed Full text at PMC Publisher
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Article in Annals of medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Wenjiang WeiDepartment of Interventional Vascular, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, PR China.
Yanying ChenDepartment of Medical Imaging, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, PR China.
Kelei HuaDepartment of Medical Imaging, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, PR China.
Bin XiaGuangdong Medical University, Zhanjiang, PR China.
Rujin LiThe Second School of Clinical Medicine, Southern Medical University, Guangdong Second Provincial General Hospital, Guangzhou, PR China.
Weizhao LinDepartment of Radiology, Jieyang People's Hospital, Jieyang, PR China.
Zichao ChenDepartment of Medical Imaging, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, PR China.
Wenqing XiaoDepartment of Medical Imaging, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, PR China.
Kanghui YuDepartment of Medical Imaging, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, PR China.
Yi YinDepartment of Medical Imaging, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, PR China.
Shoujun XuDepartment of Radiology, Shenzhen Children's Hospital, Shenzhen, PR China.
Yunfan WuDepartment of Medical Imaging, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAdenomyosis (AM) with dysmenorrhea (AMD) is a global public health concern that may involve abnormal brain function and heightened vulnerability to anxiety and depression. This study aimed to investigate static and dynamic regional homogeneity (sReHo and dReHo) alterations in AMD and their associations with clinical symptoms.

methodsFifty-two patients with AMD and 52 age- and education-matched healthy controls (HCs) underwent resting-state functional magnetic resonance imaging (rs-MRI). sReHo and dReHo maps were generated and compared using two-sample

resultsCompared with HCs, AMD patients showed significantly increased sReHo and dReHo in the right fusiform gyrus (FFG;

conclusionsAMD is characterized by altered intrinsic brain activity in pain- and emotion-related regions, supporting a central mechanism underlying chronic pain and affective symptoms. These findings provide neuroimaging evidence for AMD-related brain dysfunction. Longitudinal studies with larger cohorts and hormonal control are warranted to confirm these results and clarify causal relationships.

Indexed as

AdenomyosisBrainDysmenorrheaEmotional RegulationAdultAnxietyBrain MappingCase-Control StudiesDepressionFemaleHumansMagnetic Resonance ImagingMiddle Agedadenomyosisanxietydepressiondynamicdysmenorrheaempathypainregional homogeneityStatic

Identifiers

PMID41614571
PMCPMC12862852

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.