ArticleEuropean stroke journal2026
The effect of minimally invasive intracerebral haematoma evacuation on early perihaematomal oedema formation.
Article in European stroke journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Minimally Invasive Evacuation for Spontaneous Supratentorial Intracerebral Hemorrhage After Contemporary Randomized Trials: Patient Selection, Timing, and Platform Choice.Therapeutics and clinical risk management · 2026Review
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Authors and funding
10 authors.
Funding
Abstract
introductionIn patients with intracerebral haemorrhage (ICH), perihaematomal oedema (PHO) is considered a marker of secondary injury and is associated with worse functional outcomes. Minimally invasive surgery (MIS) has been suggested to reduce PHO when performed within 72 h of symptom onset. However, the effect of early surgery on PHO formation remains unclear. We aimed to determine the effect of MIS within 8 h of ICH onset on PHO formation. PATIENTS AND
methodsWe included patients with spontaneous, supratentorial ICH ≥10 mL undergoing MIS within 8 h from the DIST-pilot study and compared them to patients receiving standard care from a cohort study. ICH and PHO volumes at baseline and 24(±12) h were manually segmented. The primary outcome was absolute PHO (aPHO) volume at 24 h. Secondary outcomes included aPHO growth between baseline, and 24 h and oedema extension distance (OED).
resultsWe included 34 patients (median age 61 years, 68% male) undergoing MIS and 16 patients (median age 65 years, 69% male) receiving standard medical care. At baseline, median ICH, aPHO and OED volume were similar between groups. Median aPHO volume at 24 h was similar between groups (median difference -3.0 mL, 95% CI, -19.4 to 9.8, P =.67), while median aPHO growth was smaller in the MIS-group (median difference -6.8 mL, 95% CI, -18.67 to 0.33, P =.002). Median OED was greater in the MIS-group (median difference 0.18 cm, 95% CI, 0.05-0.40, P =.002).
conclusionAbsolute PHO growth in the first 24 h after ICH was less pronounced after early MIS than after standard care, suggesting that early MIS may ameliorate secondary injury after ICH.
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