Evidence map›Paper›PMID 41614501›Full record

ArticleEuropean stroke journal2026

Hemorrhagic transformation during inter-hospital transfer for thrombectomy: Incidence, associated factors, and relationship with outcome.

Pierre Seners, Adrien Ter Schiphorst, Anke Wouters, Nicole Yuen, Michael Mlynash, Caroline Arquizan, Jeremy J Heit, Denis Sablot, Anne Wacongne, Thibault Lalu and 3 more

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In one paragraph

Article in European stroke journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Pierre SenersNeurology Department, Hôpital Fondation A. de Rothschild, Paris, France.ORCID 0000-0002-2134-0691
Adrien Ter SchiphorstUniversité Paris Cité, Institute of Psychiatrie and Neurosciences of Paris (IPNP), INSERM U1266, Team Turc, Paris, France.
Anke WoutersStanford Stroke Center, Palo Alto, CA, USA.ORCID 0000-0001-5229-2699
Nicole YuenStanford Stroke Center, Palo Alto, CA, USA.
Michael MlynashStanford Stroke Center, Palo Alto, CA, USA.
Caroline ArquizanUniversité Paris Cité, Institute of Psychiatrie and Neurosciences of Paris (IPNP), INSERM U1266, Team Turc, Paris, France.ORCID 0000-0001-7347-1039
Jeremy J HeitRadiology Department, Stanford University, Palo Alto, CA, USA.ORCID 0000-0003-1055-8000
Denis SablotNeurology Department, CH Perpignan, Perpignan, France.ORCID 0000-0002-9038-7119
Anne WacongneNeurology Department, CHU Nimes, Nimes, France.
Thibault LaluNeurology Department, CH Béziers, Béziers, France.
Vincent CostalatNeuroradiology Department, CHRU Gui de Chauliac, Montpellier, France.
Gregory W AlbersStanford Stroke Center, Palo Alto, CA, USA.
Maarten G LansbergStanford Stroke Center, Palo Alto, CA, USA.

Funding

CLC NIH HHSEdmond de Rothschild FoundationFondation Bettencourt SchuellerFulbright AssociationInstitut ServierPhilippe FoundationRotary Foundation
6 · The paper itself

Abstract

backgroundPatients with acute ischemic stroke with a large vessel occlusion (AIS-LVO) admitted to primary stroke centers (PSC) often require inter-hospital transfer to a comprehensive stroke center (CSC) for endovascular therapy (EVT). We aimed to determine the incidence of hemorrhagic transformation (HT) occurring during transfer, the factors associated with HT, and its relationship with 3-month outcome.

methodsWe retrospectively analyzed data from two cohorts of AIS-LVO patients transferred from a PSC to a CSC for consideration of EVT. Patients were included if they had evidence of an anterior circulation AIS-LVO at the PSC and had a standard-of-care control brain imaging upon CSC arrival. HT was defined as any new hemorrhagic lesion within brain parenchyma visible on CSC admission imaging. Among HT patients, HT expansion was defined as an absolute volume increase of ⩾6 mL and a relative growth of ⩾33% between admission imaging and 24-h follow-up.

resultsOverall, 566 patients were included, of whom 31 (5.5%) experienced HT during transfer. Inter-hospital HT was independently associated with inter-hospital arterial recanalization (adjusted odds ratio (aOR) = 6.95, 95%CI 2.94-16.39), higher pre-transfer NIHSS score (aOR = 1.08, 95%CI 1.02-1.14), and longer time from symptom onset to CSC arrival (aOR = 1.09, 95%CI 1.04-1.13). HT expansion between CSC arrival and 24 h occurred in 24% of HT cases. Inter-hospital HT was independently associated with modified Rankin scale ⩾3 at 3-month (aOR = 3.54, 95%CI 1.08-11.67, p = 0.038).

conclusionHT during inter-hospital transfer for EVT is an uncommon event, yet is associated with a high rate of subsequent expansion and poor 3-month functional outcome. Treatments to reduce HT risk may be considered.

Indexed as

Cerebral HemorrhageIschemic StrokePatient TransferStrokeThrombectomyAgedAged, 80 and overEndovascular ProceduresFemaleHumansIncidenceMaleMiddle AgedRetrospective StudiesRisk FactorsTreatment Outcomeischemic strokethrombectomyThrombolysistransfer

Identifiers

PMID41614501
PMCPMC12866271

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.