Evidence map›Paper›PMID 41614498›Full record

ArticleEuropean stroke journal2026

Does the susceptibility vessel sign influence the effectiveness of intravenous thrombolysis before endovascular thrombectomy in acute ischaemic stroke?

Timothée Werlé, Florent Wijanto, Emilien Micard, Bailiang Chen, Marine Beaumont, Kevin Janot, Marco Pasi, Joseph Benzakoun, Jean Philippe Cottier, Bertrand Lapergue and 2 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in European stroke journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Timothée WerléDiagnostic and Interventional Neuroradiology Department, University Hospital of Tours, Tours, France.
Florent WijantoDepartment of Neurology, Foch Hospital, Versailles Saint-Quentin en Yvelines University, Suresnes, France.
Emilien MicardCIC, Innovation Technologique, CHRU-Nancy, INSERM, Université de Lorraine, Nancy, France.
Bailiang ChenCIC, Innovation Technologique, CHRU-Nancy, INSERM, Université de Lorraine, Nancy, France.
Marine BeaumontCIC, Innovation Technologique, CHRU-Nancy, INSERM, Université de Lorraine, Nancy, France.
Kevin JanotDiagnostic and Interventional Neuroradiology Department, University Hospital of Tours, Tours, France.
Marco PasiDepartment of Neurology, University Hospital of Tours INSERM, U1253, Tours, France.
Joseph BenzakounNeuroradiology Department, Hôpital Sainte Anne, GHU-Paris Psychiatrie et Neurosciences, Paris, France.
Jean Philippe CottierDiagnostic and Interventional Neuroradiology Department, University Hospital of Tours, Tours, France.
Bertrand LapergueDepartment of Neurology, Foch Hospital, Versailles Saint-Quentin en Yvelines University, Suresnes, France.
Grégoire BoulouisDiagnostic and Interventional Neuroradiology Department, University Hospital of Tours, Tours, France.
Fouzi BalaDiagnostic and Interventional Neuroradiology Department, University Hospital of Tours, Tours, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe benefit of intravenous thrombolysis (IVT) prior to EVT in acute ischaemic stroke (AIS) remains debated. We evaluated the association of the susceptibility vessel sign (SVS) with clinical and angiographic outcomes and assessed whether its presence modified the effect of IVT. PATIENTS AND

methodsWe retrospectively analysed patients with anterior circulation large vessel occlusion from the multicentre ETIS registry who underwent EVT. Susceptibility vessel sign presence and extent were assessed on MRI and categorised as binary (SVS- vs SVS+) and 3-class (SVS-, SVS+, SVS++) variables. Multivariable regression was used to evaluate associations and interactions between SVS and IVT for the primary (90-day mRS 0-2) and secondary (90-day ordinal mRS and mortality, first-pass expanded thrombolysis in cerebral infarction [eTICI] 2c-3 and final eTICI 2b-3) outcomes.

resultsAmong the 1250 patients analysed, 909 were included. Susceptibility vessel sign was present in 84.5% of patients and associated with improved 90-day mRS 0-2: adjusted odds ratio (aOR) 2.03; 95% CI, 1.18-3.46. No interaction between SVS and IVT was observed for clinical outcomes. However, SVS modified the effect of IVT on final TICI 2b-3 (Pinteraction = .03): IVT + EVT was associated with higher odds of successful reperfusion in SVS+ patients (aOR 2.00; 95% CI, 1.28-3.52) but not in SVS- patients (aOR 0.60; 95% CI, 0.16-1.97). In a secondary analysis using 3-class SVS, only SVS++ (larger hyposignal) was significantly associated with better outcomes and showed interaction with IVT for final eTICI 2b-3.

conclusionSusceptibility vessel sign, particularly SVS++, was associated with improved clinical outcomes and enhanced the effect of IVT on reperfusion success in EVT-treated AIS.

Indexed as

Endovascular ProceduresFibrinolytic AgentsIschemic StrokeThrombectomyThrombolytic TherapyAgedAged, 80 and overFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedRegistriesRetrospective StudiesTreatment OutcomeFibrinolytic Agentsmagnetic resonance imagingocclusionstrokethrombectomythrombolysis

Identifiers

PMID41614498
PMCPMC12866273

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.