ArticleEuropean stroke journal2026
Characteristics of patients with extracranial cervical artery dissections involving more than a single vessels: A subgroup analysis of STOP-CAD.
Article in European stroke journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
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Corrections and comments
- Erratum issued
Authors and funding
23 authors.
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Abstract
introductionCervical arterial dissections (CeAD) can involve either single (sCeAD) or multiple (mCeAD) arteries. Whether the involvement of a single versus multiple arteries is associated with outcomes remains unclear. We aimed to study associations between the number of affected arteries and clinical, imaging and outcome parameters. PATIENTS AND
methodsPatients with CeAD from the STOP-CAD multicenter registry study were included. Clinical, imaging, treatment and outcome parameters were compared between patients with sCeAD and mCeAD. Regression analyses were performed to identify associations with multi-arteries involvement.
resultsOverall, 3858 STOP-CAD patients were included in this analysis and 443 (11.5%) had mCeAD. The presence of mCeAD was associated with age (adjusted odds ratio [aOR] 95% confidence intervals [95% CI] 0.99; (0.98-1.00)), female sex (aOR 1.5; 95% CI 1.17-1.91), recent upper respiratory infection (aOR 2.25; 95% CI 1.55-3.27), presence of connective tissue disease (aOR 3.11; 95% CI 2.32-4.17), severe arterial stenosis (aOR 1.95; 95% CI 1.95-2.58), intracranial extension (aOR 1.47; 95% CI 1.04-2.09), vertebral artery involvement (aOR 2.50; 95% CI 1.94-3.22) and presence of dissecting aneurysm (aOR 2.59; 95% CI 1.95-3.42). In adjusted analyses, mCeAD was not associated with clinical outcomes (ischemic stroke, mortality, and sICH; all p > 0.05).
conclusionsmCeAD does not appear to increase risk of subsequent stroke as compared to sCAD despite baseline risk factors suggestive of vasculopathy. mCeAD patients who did develop a stroke presented with milder strokes and less often had vessel occlusions compared to those with sCeAD. The presence of mCeAD did not impact outcomes.
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