Evidence map›Paper›PMID 41614319›Full record

ArticleJournal of the American Heart Association2026

Prognostic Value of Artificial Intelligence-Enabled Electrocardiography-Derived Diastolic Dysfunction Grading and Trajectory in Patients Undergoing Transcatheter Aortic Valve Replacement.

Chieh-Mei Tsai, Jwan A Naser, Gal Tsaban, Eunjung Lee, Julia Wood, Allen S Luis, Jeremy J Thaden, Garvan C Kane, Sorin V Pislaru, Trevor J Simard and 4 more

Abstract read
In one paragraph

Article in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Chieh-Mei TsaiDepartment of Cardiovascular Medicine Mayo Clinic Rochester Minnesota.ORCID 0000-0002-8052-6664
Jwan A NaserDepartment of Cardiovascular Medicine Mayo Clinic Rochester Minnesota.ORCID 0000-0002-6210-7669
Gal TsabanDepartment of Cardiovascular Medicine Mayo Clinic Rochester Minnesota.ORCID 0000-0003-4234-6504
Eunjung LeeDepartment of Quantitative Health Sciences Mayo Clinic Rochester Minnesota.ORCID 0000-0002-6476-9527
Julia WoodDepartment of Quantitative Health Sciences Mayo Clinic Rochester Minnesota.
Allen S LuisDepartment of Cardiovascular Medicine Mayo Clinic Rochester Minnesota.ORCID 0000-0001-9821-1225
Jeremy J ThadenDepartment of Cardiovascular Medicine Mayo Clinic Rochester Minnesota.ORCID 0000-0003-4489-2349
Garvan C KaneDepartment of Cardiovascular Medicine Mayo Clinic Rochester Minnesota.
Sorin V PislaruDepartment of Cardiovascular Medicine Mayo Clinic Rochester Minnesota.ORCID 0000-0002-5256-3150
Trevor J SimardDepartment of Cardiovascular Medicine Mayo Clinic Rochester Minnesota.ORCID 0000-0001-9465-8150
Kevin L GreasonDepartment of Cardiovascular Surgery Mayo Clinic Rochester Minnesota.ORCID 0000-0002-1044-0750
Mackram F EleidDepartment of Cardiovascular Medicine Mayo Clinic Rochester Minnesota.ORCID 0000-0001-6082-5379
Vuyisile T NkomoDepartment of Cardiovascular Medicine Mayo Clinic Rochester Minnesota.ORCID 0000-0001-6095-5579
Jae K OhDepartment of Cardiovascular Medicine Mayo Clinic Rochester Minnesota.ORCID 0000-0002-8303-5780

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundArtificial intelligence (AI)-enabled electrocardiography has emerged as a tool for detecting cardiac dysfunction. The prognostic relevance of AI-enabled electrocardiography-derived diastolic dysfunction (DD) in patients undergoing transcatheter aortic valve replacement had not been assessed.

methodsWe analyzed 3197 patients undergoing transcatheter aortic valve replacement for severe aortic stenosis between 2010 and 2023 with baseline 12-lead ECGs processed by a validated AI model to classify diastolic function (grades 0-3). Multivariable Cox models and nested model comparisons assessed associations with all-cause mortality, including a prespecified analysis in patients with indeterminate echocardiographic grading. Trajectories were defined by change in AI-enabled electrocardiography DD grade (<2 versus ≥2) from baseline to 30-day or 1-year follow-up.

resultsAt baseline, 21% had grade 3, 57% had grade 2, 8% had grade 1, and 14% had grade 0 AI-enabled electrocardiography DD. Higher grades were associated with adverse cardiac remodeling and comorbidities. Over a median follow-up of 3.4 years, grade 3 AI-enabled electrocardiography DD independently predicted mortality (hazard ratio [HR], 1.80 [95% CI, 1.47-2.20];

conclusionsAI-enabled electrocardiography-derived DD independently predicts mortality after transcatheter aortic valve replacement, adds value beyond echocardiographic grading, and enables dynamic risk stratification through longitudinal tracking.

Indexed as

Aortic ValveAortic Valve StenosisArtificial IntelligenceElectrocardiographyTranscatheter Aortic Valve ReplacementVentricular Dysfunction, LeftVentricular Function, LeftAgedAged, 80 and overDiastoleFemaleHumansIntelligent SystemsMalePredictive Value of TestsPrognosisartificial intelligencediastolic dysfunctionechocardiographyelectrocardiographytranscatheter aortic valve replacement

Identifiers

PMID41614319
PMCPMC13055458

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.