ArticleJournal of the American Heart Association2026
Cardiac Lymphatics Predict Survival After Heart Transplantation.
Article in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Lymphatic Endothelial Cells in Health and Disease.MedComm · 2026Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCardiac allograft vasculopathy (CAV) is the leading cause of late allograft loss and a major factor limiting long-term survival after orthotopic heart transplantation (OHT). Cardiac lymphatics are severed at the time of donor heart explantation and not surgically reconstructed, potentially disrupting homeostatic processes. We examined whether variations in cardiac lymphatics could influence CAV and OHT outcomes by using endomyocardial biopsies.
methodsThe study is a single-center, blinded, retrospective case-control study using endomyocardial biopsies from 50 patients with primary OHT in the Emory Transplant Center (Atlanta, GA). Routine endomyocardial biopsies were obtained at 1 and 5 years after OHT, and angiograms were graded for CAV (no CAV
resultsWhen the number of lymphatics/mm
conclusionsThese findings indicate a potential association between reduced lymphatics and CAV, where upon further validation lymphatic area might serve as a measurable parameter to identify patients at risk for CAV and mortality. Because the survival analysis included limited adjustments, additional studies will be needed to incorporate key clinical confounders capable of influencing the relationship between lymphatic development and OHT outcomes. Future studies should investigate the mechanistic link between cardiac lymphatics and CAV and if lymphangiogenic pathways have therapeutic potential to improve OHT outcomes.
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