Observational studyJournal of the American Heart Association2026
Association Between High-Density Lipoprotein Cholesterol Levels and Prognoses in Patients With Stroke.
Observational study in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe aimed to evaluate the prognostic effect of serum high-density lipoprotein cholesterol (HDL-c) concentration on the risk of vascular events and functional prognosis in patients with stroke.
methodsIn this prospective observational study, patients with ischemic stroke were consecutively enrolled within 1 week of symptom onset and followed up for 1 year. Patients were divided into 3 groups according to tertiles of serum HDL-c levels (tertile 1, <47 mg/dL; tertile 2, 47-60 mg/dL; and tertile 3, >60 mg/dL). The primary outcome was a composite of major adverse cardiovascular events, including nonfatal stroke, nonfatal acute coronary syndrome, major peripheral artery disease, and vascular death. The secondary outcome was the modified Rankin scale score.
resultsA total of 865 patients (mean age, 70.2 years; male, 61.1%) were included. High HDL-c levels were associated with older age, female sex, low body mass index, nonsmoking, and low prevalences of diabetes and coronary artery disease. No significant differences were found in the risk of major adverse cardiovascular events between the 3 groups (annual rates: 17.5%, 11.2%, and 12.4% in tertiles 1, 2, and 3, respectively; log-rank
conclusionsNo correlations were observed between HDL-c levels and vascular event risk; however, elevated HDL-c concentrations were associated with favorable functional recovery in patients with stroke. REGISTRATION: https://upload.umin.ac.jp; Unique Identifier: UMIN000031913.
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