Evidence map›Paper›PMID 41614244›Full record

ArticleHuman brain mapping2026

Neurostructural Substrates of Hierarchical Dimensions of Internalizing Symptoms in Youth.

E Leighton Durham, Tyler M Moore, Kaitlynn E Ellis, Shuti Wang, Hee Jung Jeong, Gabrielle E Reimann, Camille Archer, Antonia N Kaczkurkin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human brain mapping, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

E Leighton DurhamDepartment of Psychology, Vanderbilt University, Nashville, Tennessee, USA.
Tyler M MooreDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0002-1384-0151
Kaitlynn E EllisDepartment of Psychology, Vanderbilt University, Nashville, Tennessee, USA.
Shuti WangDepartment of Psychology, Vanderbilt University, Nashville, Tennessee, USA.
Hee Jung JeongDepartment of Psychology, Vanderbilt University, Nashville, Tennessee, USA.
Gabrielle E ReimannDepartment of Psychology, Vanderbilt University, Nashville, Tennessee, USA.
Camille ArcherDepartment of Psychology, Vanderbilt University, Nashville, Tennessee, USA.
Antonia N KaczkurkinDepartment of Psychology, Vanderbilt University, Nashville, Tennessee, USA.ORCID https://orcid.org/0000-0002-0943-3094

Funding

ABCD-USA Consortium: Coordinating CenterU24DA041147 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SANDRA A BROWN, TERRY L. JERNIGAN · 2015 to 2026
$54.7M
ABCD-USA Consortium: Data Analysis, Informatics and Resource CenterU24DA041123 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ANDERS M DALE · 2015 to 2026
$51.5M
Adolescent Substance Use Initiation: Disentangling neurocognitive risks from consequences using longitudinal and genetically-informed methodsU01DA041120 · NIDA · UNIVERSITY OF MINNESOTA · PI Monica Luciana, Sylia Wilson · 2015 to 2026
$34.5M
ABCD-USA Consortium: Research ProjectU01DA041089 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Joanna Jacobus, Susan F. Tapert · 2015 to 2026
$31.7M
Prospective Research Studies of Maturation (PRISM)- Research ProjectU01DA041134 · NIDA · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI ERIN MCGLADE, PERRY FRANKLIN RENSHAW · 2015 to 2026
$29.2M
ABCD-USA CONSORTIUM: RESEARCH PROJECTU01DA041048 · NIDA · CHILDREN'S HOSPITAL OF LOS ANGELES · PI Megan Marie Herting, ELIZABETH R SOWELL · 2015 to 2026
$28.7M
ABCD-USA Consortium: Research ProjectU01DA041106 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mary M Heitzeg, Chandra Sekhar Sripada · 2015 to 2026
$24.9M
FIU-ABCD: Pathways and Mechanisms to Addiction in the Latino Youth of South FloridaU01DA041156 · NIDA · FLORIDA INTERNATIONAL UNIVERSITY · PI Raul Gonzalez, Angela R Laird · 2015 to 2026
$22.8M
ABCD-USA Consortium: Research ProjectU01DA041148 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Damien A Fair, Rebekah S Huber · 2015 to 2026
$22.3M
ABCD-USA: NYC Research ProjectU01DA041174 · NIDA · YALE UNIVERSITY · PI Arielle Ryan Baskin-Sommers, Betty J Casey · 2015 to 2026
$19.7M
Adolescent Brain Cognitive Development (ABCD) Prospective Research in Studies of Maturation (PRISM) ConsortiumU01DA041117 · NIDA · UNIVERSITY OF MARYLAND BALTIMORE · PI LINDA CHANG, THOMAS M ERNST · 2015 to 2026
$19.5M
15/21 ABCD-USA Consortium: Research Project Site at LIBRU01DA050989 · NIDA · LAUREATE INSTITUTE FOR BRAIN RESEARCH · PI ROBIN L AUPPERLE, MARTIN P. PAULUS · 2020 to 2026
$14.7M
American Psychological FoundationBrain & Behavior Research Foundation 30891Children's Hospital of PhiladelphiaLifespan Brain Institute of the University of PennsylvaniaNational Science Foundation Graduate Research Fellowship Program 1937963NICHD NIH HHS P50 HD103537NIDA NIH HHS U01 DA041022NIDA NIH HHS U01 DA041025NIDA NIH HHS U01 DA041028NIDA NIH HHS U01 DA041048NIDA NIH HHS U01 DA041089NIDA NIH HHS U01 DA041093NIDA NIH HHS U01 DA041106NIDA NIH HHS U01 DA041117NIDA NIH HHS U01 DA041120NIDA NIH HHS U01 DA041134NIDA NIH HHS U01 DA041148NIDA NIH HHS U01 DA041156NIDA NIH HHS U01 DA041174NIDA NIH HHS U01 DA050987NIDA NIH HHS U01 DA050988NIDA NIH HHS U01 DA050989NIDA NIH HHS U01 DA051016NIDA NIH HHS U01 DA051018NIDA NIH HHS U01 DA051037NIDA NIH HHS U01 DA051038NIDA NIH HHS U01 DA051039NIDA NIH HHS U24 DA041123NIDA NIH HHS U24 DA041147NIH HHS U01DA041022NIH HHS U01DA041025NIH HHS U01DA041028NIH HHS U01DA041048NIH HHS U01DA041089NIH HHS U01DA041093NIH HHS U01DA041106NIH HHS U01DA041117NIH HHS U01DA041120NIH HHS U01DA041134NIH HHS U01DA041148NIH HHS U01DA041156NIH HHS U01DA041174NIH HHS U01DA050987NIH HHS U01DA050988NIH HHS U01DA050989NIH HHS U01DA051016NIH HHS U01DA051018NIH HHS U01DA051037NIH HHS U01DA051038NIH HHS U01DA051039NIH HHS U24DA041123NIH HHS U24DA041147NIMH NIH HHS R00 MH117274NIMH NIH HHS R00MH117274NIMH NIH HHS R01 MH117014NIMH NIH HHS R01MH117014NIMH NIH HHS T32 MH018921NIMH NIH HHS T32-MH18921Sloan Research Fellowship FG-2020-13449
6 · The paper itself

Abstract

Internalizing symptoms are common in childhood and linked to meaningful differences in brain structure, yet their organization and neurobiological correlates during this developmental period remain poorly understood. An increasing number of studies conceptualize internalizing psychopathology as dimensional, transdiagnostic, and hierarchical, yet the factor structure of these symptoms in youth remains to be clearly defined. Additionally, the neurostructural underpinnings of internalizing factors warrants further investigation in younger samples. Using a large sample (N = 11,868) of 9- to 10-year-old children from the Adolescent Brain Cognitive Development

Indexed as

Cerebral CortexGray MatterChildFearFemaleHumansMagnetic Resonance ImagingMalebrain structurehierarchical modelinginternalizing symptomsyouth

Identifiers

PMID41614244
PMCPMC12856526

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.