Evidence map›Paper›PMID 41614241›Full record

ArticleCirculation. Cardiovascular imaging2026

Multicenter Evaluation of Myocardial Flow Reserve as a Prognostic Marker for Mortality in

Giselle Ramirez, Valerie Builoff, Robert J H Miller, Mark Lemley, Isabel Carvajal-Juarez, Erick Alexanderson, Thomas L Rosamond, Na Song, Mark I Travin, Leandro Slipczuk and 5 more

Abstract readMulticenter Study
In one paragraph

Article in Circulation. Cardiovascular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Giselle Ramirez *Artificial Intelligence in Medicine Research Center, Departments of Biomedical Sciences, Medicine, and Cardiology, Cedars-Sinai Medical Center, Los Angeles, CA (G.R., V.B., R.J.H.M., M.L., P.J.S.).
Valerie Builoff *Artificial Intelligence in Medicine Research Center, Departments of Biomedical Sciences, Medicine, and Cardiology, Cedars-Sinai Medical Center, Los Angeles, CA (G.R., V.B., R.J.H.M., M.L., P.J.S.).ORCID 0009-0006-4838-3700
Robert J H MillerArtificial Intelligence in Medicine Research Center, Departments of Biomedical Sciences, Medicine, and Cardiology, Cedars-Sinai Medical Center, Los Angeles, CA (G.R., V.B., R.J.H.M., M.L., P.J.S.).ORCID 0000-0003-4676-2433
Mark LemleyArtificial Intelligence in Medicine Research Center, Departments of Biomedical Sciences, Medicine, and Cardiology, Cedars-Sinai Medical Center, Los Angeles, CA (G.R., V.B., R.J.H.M., M.L., P.J.S.).ORCID 0000-0002-1531-880X
Isabel Carvajal-JuarezDepartment of Nuclear Cardiology, Ignacio Chavez National Institute of Cardiology, Mexico City, Mexico (I.C.-J., E.A.).ORCID 0000-0001-8764-6012
Erick AlexandersonDepartment of Nuclear Cardiology, Ignacio Chavez National Institute of Cardiology, Mexico City, Mexico (I.C.-J., E.A.).
Thomas L RosamondDepartment of Cardiovascular Medicine, The University of Kansas Medical Center, Kansas City (T.L.R.).
Na SongDepartment of Radiology (Nuclear Medicine), Montefiore Medical Center and the Albert Einstein College of Medicine, Bronx, NY (N.S., M.I.T., L.S.).ORCID 0000-0003-0552-712X
Mark I TravinDepartment of Radiology (Nuclear Medicine), Montefiore Medical Center and the Albert Einstein College of Medicine, Bronx, NY (N.S., M.I.T., L.S.).ORCID 0000-0003-0968-2143
Leandro SlipczukDepartment of Radiology (Nuclear Medicine), Montefiore Medical Center and the Albert Einstein College of Medicine, Bronx, NY (N.S., M.I.T., L.S.).ORCID 0000-0003-3091-3735
Andrew J EinsteinDivision of Cardiology, Departments of Medicine and Radiology, Columbia University Irving Medical Center and New York-Presbyterian Hospital, New York (A.J.E.).ORCID 0000-0003-2583-9278
Samuel B WoppererDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (S.B.W., P.C.).
Marcelo F Di CarliDivision of Nuclear Medicine and Molecular Imaging, Department of Radiology, Brigham and Women's Hospital, Boston, MA (M.F.D.C.).ORCID 0000-0003-3119-025X
Panithaya ChareonthaitaweeDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (S.B.W., P.C.).ORCID 0000-0002-3811-8712
Piotr J SlomkaArtificial Intelligence in Medicine Research Center, Departments of Biomedical Sciences, Medicine, and Cardiology, Cedars-Sinai Medical Center, Los Angeles, CA (G.R., V.B., R.J.H.M., M.L., P.J.S.).ORCID 0000-0002-6110-938X

Funding

Patient-specific Outcome Prediction from Cardiovascular Multimodality Imaging by Artificial IntelligenceR35HL161195 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI Piotr J Slomka · 2022 to 2026
$5.0M
Integrating Artificial Intelligence for Optimal Analysis of CardiacPET/CTR01EB034586 · NIBIB · CEDARS-SINAI MEDICAL CENTER · PI DI CARLI, MARCELO F, SLOMKA, PIOTR J · 2022 to 2025
$2.9M
NHLBI NIH HHS R35 HL161195NIBIB NIH HHS R01 EB034586
6 · The paper itself

Abstract

backgroundMyocardial flow reserve (MFR), measured by positron emission tomography (PET) myocardial perfusion imaging, provides valuable information on epicardial coronary disease, diffuse atherosclerosis, and microvascular function. Despite its routine use, the prognostic efficacy of

methodsWe considered patients from 5 sites in the REFINE PET (Registry of Flow and Perfusion Imaging for Artificial Intelligence with PET) registry who underwent

resultsIn total, 6277 patients were included (median age of 65 years, 56% male). Median follow-up time was 3.8 years. There were 1895 patients with MFR ≤2 and 4382 with MFR >2. Patients with MFR ≤2 had significantly higher mortality than those with MFR >2 (n=701 [37.0%] versus n=537 [12.3%], respectively;

conclusionsIn this large multicenter cohort, MFR derived from

Indexed as

AmmoniaCoronary Artery DiseaseFractional Flow Reserve, MyocardialMyocardial Perfusion ImagingNitrogen RadioisotopesPositron-Emission TomographyRadiopharmaceuticalsAgedFemaleHumansKaplan-Meier EstimateMaleMiddle AgedPredictive Value of TestsPrognosisProportional Hazards ModelsAmmoniaNitrogen-13Nitrogen RadioisotopesRadiopharmaceuticalsammoniacoronary artery diseasemortalityperfusionpositron-emission tomography

Identifiers

PMID41614241
PMCPMC13016269

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.