ArticleJournal of cell science2026
Uncovering mitotic ultrastructure in the native hair follicle using volume electron microscopy.
Article in Journal of cell science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
The hair follicle undergoes repeated cycles, with anagen representing the active growth phase. During anagen, transit amplifying cells within the germinative matrix at the follicle bulb drive rapid proliferation for hair growth. This region exhibits some of the highest mitotic rates observed in any tissue, offering a rare opportunity to study mitosis in its native epithelial context, previously studied only in cultured cell lines. We applied volume electron microscopy to intact chemically fixed hair follicles enabling exceptional ultrastructural preservation of the entire mini-organ. Morphometric analysis revealed stage-specific changes in chromosomal and organelle volume and spatial distribution, highlighting coordinated roles for the mitochondria, vesicles and endoplasmic reticulum, and enabled, to our knowledge, the first ultrastructure-based karyotype of ovine chromosomes. This work advances understanding of mitosis by resolving ultrastructure in a highly proliferative, spatially constrained epithelial microenvironment, demonstrating the power of serial block face scanning electron microscopy to bridge in vitro models and native tissue architecture.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.