ArticleJACS Au2026
Methanol-Mediated Nickel-Catalyzed Chemo- and Enantioselective Three-Component Alkenylative Coupling of Aldimines and Alkynes with Alkenyl Boronic Acids.
Article in JACS Au, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
1,3-Dienyl amines are important and versatile motifs in organic synthesis, and the functionalization of π-components with aldimines has emerged as a powerful strategy for their construction. However, existing methods typically rely on conjugated enynes or dienes and are limited to two-component reactions. Herein, we report a nickel-catalyzed chemoselective three-component alkenylative coupling of aldimines, simple alkynes, and alkenyl boronic acids, which provides stereodefined, multisubstituted 1,3-dienyl amines in good to excellent yields (up to 97% yield). Methanol acts as a sustainable protic solvent, facilitating the ring opening of the aza-nickelacycle intermediate generated via oxidative cyclization of the aldimine and alkyne. Furthermore, employing a
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